Inflammation as a Driver of Adverse Left Ventricular Remodeling after Acute Myocardial Infarction

Peter C. Westman, Michael J. Lipinski, Dror Luger, Ron Waksman, Robert O. Bonow, Edwin Wu, Stephen E. Epstein*

*Corresponding author for this work

Research output: Contribution to journalReview article

154 Scopus citations

Abstract

Treatment of acute myocardial infarction (AMI) has improved significantly in recent years, but many patients have adverse left ventricular (LV) remodeling, a maladaptive change associated with progressive heart failure. Although this change is usually associated with large infarcts, some patients with relatively small infarcts have adverse remodeling, whereas other patients with larger infarcts (who survive the first several days after AMI) do not. This paper reviews the relevant data supporting the hypothesis that individual differences in the intensity of the post-AMI inflammatory response, involving 1 or more inflammatory-modulating pathways, may contribute to adverse LV remodeling. It concludes by outlining how individual variations in the inflammatory response could provide important novel therapeutic targets and strategies.

Original languageEnglish (US)
Pages (from-to)2050-2060
Number of pages11
JournalJournal of the American College of Cardiology
Volume67
Issue number17
DOIs
StatePublished - May 3 2016

Keywords

  • heart failure
  • infarct size
  • left ventricular function
  • stem cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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