INFLAMMATION | Cerebrovascular Diseases, Seizures, and Epilepsy

N. Marchi*, Ayush Batra, I. Tuxhorn, T. Granata, M. de Curtis, D. Janigro

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


While epilepsies affect approximately 1% of the population, seizures occur in a larger population of subjects. Clear clinical differences exist between seizures and epileptic syndromes. While repetitive seizure activity is a hallmark of epilepsy, seizures may be observed clinically as a result of pathological processes initiated outside the central nervous system (CNS). The latter include systemic diseases associated with inflammation, stroke, anoxia, and hemodynamic changes. The probability of seizure occurrence increases during iatrogenic vascular interventions (e.g., cardiopulmonary bypass or blood–brain barrier opening) due to alteration of cerebral blood flow and increased permeability of the blood–brain barrier (BBB). In this article, we present evidence suggesting the role of intravascular pathological events in setting seizure threshold.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Basic Epilepsy Research
Number of pages11
ISBN (Electronic)9780123739612
StatePublished - Jan 1 2009


  • Blood–brain barrier
  • Brain homeostasis
  • Cerebrovascular dysplasia
  • Intravascular inflammation
  • Lithium chloride
  • Neurovascular unit
  • Osmotic opening
  • Pilocarpine
  • Seizure
  • Systemic inflammation
  • Vascular permeability

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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