Inflammatory acne management with a novel prescription dietary supplement

Alan R. Shalita, Ronald Falcon, Alan Olansky, Patricia Iannotta, Arash Akhavan, Doris Day, Anthony Janiga, Prashant Singri, John E. Kallal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: Inflammatory acne, particularly in postadolescent women, is increasing in incidence. The most effective therapeutic modality for treatment of this type of acne has been the administration of oral tetracyclines. Long-term acne treatment with such drugs, however, is frequently accompanied by undesirable adverse reactions, including gastrointestinal disturbances, antianabolic effects, headaches, tinnitus, and photosensitivity. Objective: To assess the usefulness of a novel dietary supplement in the overall management of patients with inflammatory acne vulgaris. Methods: 235 patients with inflammatory acne vulgaris were enrolled by dermatologists in a multicenter, open-label, 8-week, prospective study evaluating the effects of adding NicAzel, 1 to 4 tablets daily, to their current acne treatment regimen. Results: A statistically significant (P<.0001) number of patients demonstrated improvement over their previous acne treatment regimens after both 4 and 8 weeks of NicAzel (nicotinamide, azelaic acid, zinc, pyridoxine, copper, folic acid; Elorac Inc, Vernon Hills, IL) use. At week 8, 88% of the patients experienced a visible reduction in inflammatory lesions, and 81% of the patients rated their appearance as much or moderately better compared with baseline. Three-quarters (76%) of the patients thought NicAzel was at least as effective as previous treatment with oral antibiotics. Conclusion: Patients with inflammatory acne showed significant improvement in acne severity and overall appearance when NicAzel was added to their existing treatment regimen.

Original languageEnglish (US)
Pages (from-to)1428-1433
Number of pages6
JournalJournal of Drugs in Dermatology
Issue number12
StatePublished - Dec 2012

ASJC Scopus subject areas

  • General Medicine


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