Abstract
Background: There are limited data examining the risk of prostate cancer (PCa) in patients with inflammatory bowel disease (IBD). Objective: To compare the incidence of PCa between men with and those without IBD. Design, setting, and participants: This was a retrospective, matched-cohort study involving a single academic medical center and conducted from 1996 to 2017. Male patients with IBD (cases = 1033) were randomly matched 1:9 by age and race to men without IBD (controls = 9306). All patients had undergone at least one prostate-specific antigen (PSA) screening test. Outcome measurements and statistical analysis: Kaplan-Meier and multivariable Cox proportional hazard models, stratified by age and race, evaluated the relationship between IBD and the incidence of any PCa and clinically significant PCa (Gleason grade group ≥2). A mixed-effect regression model assessed the association of IBD with PSA level. Results and limitations: PCa incidence at 10 yr was 4.4% among men with IBD and 0.65% among controls (hazard ratio [HR] 4.84 [3.34–7.02] [3.19–6.69], p < 0.001). Clinically significant PCa incidence at 10 yr was 2.4% for men with IBD and 0.42% for controls (HR 4.04 [2.52–6.48], p < 0.001). After approximately age 60, PSA values were higher among patients with IBD (fixed-effect interaction of age and patient group: p = 0.004). Results are limited by the retrospective nature of the analysis and lack of external validity. Conclusions: Men with IBD had higher rates of clinically significant PCa when compared with age- and race-matched controls. Patient summary: This study of over 10 000 men treated at a large medical center suggests that men with inflammatory bowel disease may be at a higher risk of prostate cancer than the general population. In a retrospective matched-cohort study, patients with inflammatory bowel disease (IBD) who underwent prostate-specific antigen-based screening had higher rates of any and clinically significant (Gleason ≥7) prostate cancer than age- and race-matched patients without IBD. Prospective studies should investigate the relationship between IBD and prostate cancer.
Original language | English (US) |
---|---|
Pages (from-to) | 846-852 |
Number of pages | 7 |
Journal | European urology |
Volume | 75 |
Issue number | 5 |
DOIs | |
State | Published - May 2019 |
Keywords
- Inflammatory bowel diseases
- Prostate-specific antigen
- Prostatic neoplasm
ASJC Scopus subject areas
- Urology