Inflammatory breast cancer the disease, the biology, the treatment

Fredika M. Robertson, Melissa Bondy, Wei Yang, Hideko Yamauchi, Shannon Wiggins, Samira Kamrudin, Savitri Krishnamurthy, Huong Le-Petross, Luc Bidaut, Audrey N. Player, Sanford H. Barsky, Wendy A. Woodward, Thomas Buchholz, Anthony Lucci, Naoto Ueno, Massimo Cristofanilli*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

224 Scopus citations

Abstract

Inflammatory breast cancer (IBC) is a rare and aggressive form of invasive breast cancer accounting for 2.5% of all breast cancer cases. It is characterized by rapid progression, local and distant metastases, younger age of onset, and lower overall survival compared with other breast cancers. Historically, IBC is a lethal disease with less than a 5% survival rate beyond 5 years when treated with surgery or radiation therapy. Because of its rarity, IBC is often misdiagnosed as mastitis or generalized dermatitis. This review examines IBC's unique clinical presentation, pathology, epidemiology, imaging, and biology and details current multidisciplinary management of the disease, which comprises systemic therapy, surgery, and radiation therapy.

Original languageEnglish (US)
Pages (from-to)351-375
Number of pages25
JournalCA Cancer Journal for Clinicians
Volume60
Issue number6
DOIs
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Hematology
  • Oncology

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