Inflammatory infratentorial progressive multifocal leukoencephalopathy in a patient with rheumatoid arthritis

Boleslaw Lach*, Barbara Connolly, Christian Wüthrich, Igor J. Koralnik

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

An 84-year-old man with rheumatoid arthritis (RA) treated with methotrexate, developed progressive confusion and cerebellar symptoms, and died approximately 2 months later. Neuropathological examination revealed progressive multifocal leukoencephalopathy (PML) involving the cerebellum and brainstem. The affected tissues displayed intense infiltrations by CD8+ T-cells and microglia. JC virus was localized in oligodendroglia and cerebellar granule cells. This case illustrates unusual localization of inflammatory PML in a patient with RA treated with methotrexate.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalNeuropathology
Volume34
Issue number1
DOIs
StatePublished - Feb 1 2014

Keywords

  • Cerebellar syndrome
  • Demyelination
  • Methotrexate
  • Progressive multifocal leukoencephalopathy
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology

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