Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice

Wen Jie Ji, Yong Qiang Ma, Xin Zhang, Li Zhang, Yi Dan Zhang, Cheng Cheng Su, Guo An Xiang, Mei Ping Zhang, Zhi Chun Lin, Lu Qing Wei, Peizhong P. Wang, Zhuoli Zhang, Yu Ming Li*, Xin Zhou

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Aim: To examine the therapeutic/preventive potential of liposome-encapsulated spironolactone (SP; Lipo-SP) for acute lung injury (ALI) and fibrosis. Materials & methods: Lipo-SP was prepared by the film-ultrasonic method, and physicochemical and pharmacokinetic characterized for oral administration (10 and 20 mg/kg for SP-loaded liposome; 20 mg/kg for free SP) in a mouse model bleomycin-induced ALI. Results: Lipo-SP enhanced bioavailability of SP with significant amelioration in lung pathology. Mechanistically, SP-mediated mineralocorticoid receptor antagonism contributes to inflammatory monocyte/macrophage modulation via an inhibitory effect on Ly6Chi monocytosis-directed M2 polarization of alveolar macrophages. Moreover, Lipo-SP at lower dose (10 mg/kg) exhibited more improvement in body weight gain. Conclusion: Our data highlight Lipo-SP as a promising approach with therapeutic/preventive potential for ALI and fibrosis.

Original languageEnglish (US)
Pages (from-to)1393-1406
Number of pages14
JournalNanomedicine
Volume11
Issue number11
DOIs
StatePublished - Jun 2016

Keywords

  • acute lung injury
  • liposome
  • pulmonary fibrosis
  • spironolactone

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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  • Cite this

    Ji, W. J., Ma, Y. Q., Zhang, X., Zhang, L., Zhang, Y. D., Su, C. C., Xiang, G. A., Zhang, M. P., Lin, Z. C., Wei, L. Q., Wang, P. P., Zhang, Z., Li, Y. M., & Zhou, X. (2016). Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice. Nanomedicine, 11(11), 1393-1406. https://doi.org/10.2217/nnm-2016-0006