Influence of age on cerebral recovery after deep hypothermic circulatory arrest in piglets

Fumikazu Nomura, Joseph M. Forbess, Richard A. Jonas*, Takeshi Hiramatsu, Adre J. Du Plessis, Gene Walter, Michael E. Stromski, David H. Holtzman

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background. In the first weeks of life there are important maturational changes in the central nervous system in many species in energy metabolism synapse number, and concentration of neuronal excitatory receptors. Methods. Four groups of 10 piglets (aged 1, 2, 4, and 10 weeks) underwent 1 hour of deep hypothermic circulatory arrest at 15°C, with cooling and rewarming on cardiopulmonary bypass. Cerebral blood flow and metabolic rate measurements and electroencephalographic recordings were obtained from 5 animals per group. The remaining animals underwent cerebral magnetic resonance spectroscopy. Results. Preoperative cerebral blood now and glucose consumption were higher at 4 and 10 weeks than at 1 and 2 weeks. Cerebral adenosine triphosphate content decreased more rapidly during deep hypothermic circulatory arrest at 4 and 10 weeks. Phosphocreatine recovery was greater at 30 minutes of reperfusion at 10 weeks compared with 1 week. Recovery of cerebral phosphocreatine/adenosine triphosphate ratio and intracellular pH was remarkably uniform at all ages. Latency to recovery of electroencephalographic activity decreased with increasing age (p = 0.04). Conclusions. Differences in acute recovery of brain energy metabolism and electroencephalogram after cardiopulmonary bypass and 1 hour of deep hypothermic circulatory arrest in piglets between 1 and 10 weeks of age are small. Further studies are required to correlate these acute findings with subsequent neurologic outcome.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalAnnals of Thoracic Surgery
Volume62
Issue number1
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Influence of age on cerebral recovery after deep hypothermic circulatory arrest in piglets'. Together they form a unique fingerprint.

  • Cite this

    Nomura, F., Forbess, J. M., Jonas, R. A., Hiramatsu, T., Du Plessis, A. J., Walter, G., Stromski, M. E., & Holtzman, D. H. (1996). Influence of age on cerebral recovery after deep hypothermic circulatory arrest in piglets. Annals of Thoracic Surgery, 62(1), 115-122. https://doi.org/10.1016/0003-4975(96)00331-1