Influence of dopamine on physicochemical and in vitro biological properties of calcium phosphate cement

Yu Liu, Shuxin Qu*, Zongguang Liu, Xiong Xiong, Zhimin Wen, Sunzhong Lin, Ding Yonghui, Yang Leng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The aim of this study is to improve the mechanical property of calcium phosphate cement (CPC) via adding of the biocompatible and adhesive dopamine (DA-CPC). The effects of DA on properties of DA-CPC were investigated by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), compressive testing and scanning electron microscopy (SEM). The morphology, proliferation and differentiation of MC3ET3-E1 osteoblast co-cultured with DA-CPC were evaluated by fluorescence microscopy, Alamar Blue assay and alkaline phosphatase assay, respectively. It is found that the conversion of α-TCP and DCPD in DA-CPC is promoted due to the self-polymerization of DA and the phases of DA-CPC are similar to those of the control CPC. Meanwhile, the compressive strengths of DA-CPC are improved significantly with the addition of DA. The presence of DA in DA-CPC could promote the adhesion and the proliferation of osteoblasts in the initial stage, while it does not affect the differentiation of the osteoblasts. The present DA-CPC has good biocompatibility to be used in clinic potentially. The present study provides a new approach to improve the mechanical strength of CPC.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalXiyou Jinshu Cailiao Yu Gongcheng/Rare Metal Materials and Engineering
StatePublished - Sep 1 2014


  • Biocompatibility
  • Calcium phosphate cement
  • Dopamine
  • Mechanical property

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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