The influence of dynorphin A (1-17) on calmodulin level and activity of PDE after intrathecal injection was investigated. Dynorphin A (1-17) (10, 20 nmol) attenuated calmodulin level and PDE activity dose-dependently, and resumed in some degree in 2 h. Nor-BNI (30 nmol), a selective k-opiate receptor antagonist, APV (10 nmol), an excitatory amino acid NMDA receptor antagonist, verapamil (100 nmol), an L-type calcium channel blocker played a role in blocking the influence of dynorphin A (1-17).
|Original language||English (US)|
|Number of pages||5|
|Journal||Chinese Pharmacological Bulletin|
|State||Published - Jan 1 1995|
- dynorphin A (1-17)
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