Influence of dynorphin A (1-17) on calmodulin level and activity of PDE in spinal cord of rats

Z. Y. Zhang*, F. C. Li, W. A. Qiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The influence of dynorphin A (1-17) on calmodulin level and activity of PDE after intrathecal injection was investigated. Dynorphin A (1-17) (10, 20 nmol) attenuated calmodulin level and PDE activity dose-dependently, and resumed in some degree in 2 h. Nor-BNI (30 nmol), a selective k-opiate receptor antagonist, APV (10 nmol), an excitatory amino acid NMDA receptor antagonist, verapamil (100 nmol), an L-type calcium channel blocker played a role in blocking the influence of dynorphin A (1-17).

Original languageEnglish (US)
Pages (from-to)455-459
Number of pages5
JournalChinese Pharmacological Bulletin
Volume11
Issue number6
StatePublished - Jan 1 1995

Keywords

  • calmodulin
  • dynorphin A (1-17)
  • phosphodiesterase

ASJC Scopus subject areas

  • Pharmacology

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