Influence of hypoxia on the longitudinal distribution of pulmonary vascular resistance

C. A. Dawson, D. J. Grimm, J. H. Linehan

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The authors have examined the influence of hypoxia on the longitudinal distribution of vascular resistance and intravascular pressure in isolated cat lungs using the low-viscosity bolus technique. Hypoxia increased total vascular resistance, decreased total lung blood volume, and moved the maximum local resistance downstream away from the main pulmonary artery. The circumference of the main pulmonary artery was increased and the extravascular lung water (double indicator dilution technique) was decreased by hypoxia. Thus, it would appear that distension of the large pulmonary arteries and a decrease in the amount of lung tissue perfused contributed to the change in resistance distribution brought about by hypoxia.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume44
Issue number4
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

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