Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study

Diddier Prada, Elena Colicino, Melinda C. Power, David G. Cox, Marc G. Weisskopf, Lifang Hou, Avron Spiro, Pantel Vokonas, Jia Zhong, Marco Sanchez-Guerra, Luis A. Herrera, Joel Schwartz, Andrea A. Baccarelli*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: APOE is the biomarker with the greatest known influence on cognitive function; however, the effect of complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never been studied in older populations. Methods: We evaluated APOE polymorphisms using multiplex PCR for genotyping and Mini-Mental State Examination (MMSE) to evaluate cognitive function in 819 individuals from VA Normative Aging Study.Results: Combinatorial analysis of all polymorphisms and individual analysis of polymorphisms rs449647, rs405509, rs440446 and rs7412 did not show any association with cognitive performance. Polymorphism rs429358 was associated with better cognitive performance (odds of MMSE ≤ 25 = 0.63, 95% CI 0.42-0.95; p = 0.03) in the oldest subsample (5th quintile of age) (odds of MMSE ≤ 25 = 0.34; 95% CI 0.13-0.86; p = 0.02). APOE allele ε4 was also associated with better cognitive performance (odds of MMSE ≤ 25 = 0.61, 95% CI 0.40-0.94; p = 0.02), also in the oldest subsample (odds of MMSE ≤ 25 = 0.35, 95% CI 0.14-0.90; p = 0.03). Conclusions: These results suggest a beneficial effect of polymorphism rs429358 in the oldest men.

Original languageEnglish (US)
Article number223
JournalBMC Psychiatry
Volume14
Issue number1
DOIs
StatePublished - Aug 1 2014

Keywords

  • APOE
  • Aging
  • Alleles
  • Cognitive decline
  • Epsilon
  • Genetic variants
  • Haplotypes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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    Prada, D., Colicino, E., Power, M. C., Cox, D. G., Weisskopf, M. G., Hou, L., Spiro, A., Vokonas, P., Zhong, J., Sanchez-Guerra, M., Herrera, L. A., Schwartz, J., & Baccarelli, A. A. (2014). Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study. BMC Psychiatry, 14(1), [223]. https://doi.org/10.1186/s12888-014-0223-x