Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response

Renan P. Souza; Herbert Y. Meltzer; Jeffrey A. Lieberman; Bernard Le Foll; James L. Kennedy

doi:10.1002/hup.1146

Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response

Renan P. Souza, Herbert Y. Meltzer, Jeffrey A. Lieberman, Bernard Le Foll, James L. Kennedy

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Schizophrenia patients show alterations in the synaptic connectivity. However, it remains unknown whether antipsychotic response may be altered depending on the synaptic connectivity. We tested this association using polymorphisms in the neurexin 1 gene (NRXN1). Large NRXN1 deletions have also been associated with schizophrenia. We genotyped four variants in 140 schizophrenia patients assessed prospectively for clozapine response after 6 months. We observed a trend toward association of clozapine response with the rs12467557 (permuted p = 0.051). These results should be read with caution before independent replication.

Original language	English (US)
Pages (from-to)	582-585
Number of pages	4
Journal	Human Psychopharmacology
Volume	25
Issue number	7-8
DOIs	https://doi.org/10.1002/hup.1146
State	Published - Nov 2010

Keywords

antipsychotics
biomarkers
personalized medicine
pharmacogenomics
schizophrenia

ASJC Scopus subject areas

Clinical Neurology
Neurology
Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hup.1146

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abstract = "Schizophrenia patients show alterations in the synaptic connectivity. However, it remains unknown whether antipsychotic response may be altered depending on the synaptic connectivity. We tested this association using polymorphisms in the neurexin 1 gene (NRXN1). Large NRXN1 deletions have also been associated with schizophrenia. We genotyped four variants in 140 schizophrenia patients assessed prospectively for clozapine response after 6 months. We observed a trend toward association of clozapine response with the rs12467557 (permuted p = 0.051). These results should be read with caution before independent replication.",

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AU - Le Foll, Bernard

AU - Kennedy, James L.

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AB - Schizophrenia patients show alterations in the synaptic connectivity. However, it remains unknown whether antipsychotic response may be altered depending on the synaptic connectivity. We tested this association using polymorphisms in the neurexin 1 gene (NRXN1). Large NRXN1 deletions have also been associated with schizophrenia. We genotyped four variants in 140 schizophrenia patients assessed prospectively for clozapine response after 6 months. We observed a trend toward association of clozapine response with the rs12467557 (permuted p = 0.051). These results should be read with caution before independent replication.

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Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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