Influence of nuclear morphology on differentiation of mesenchymal stem cells

Xinlong Wang, Vasundhara Agrawal, Chongwen Duan, Bin Jiang, Vadim Backman, Guillermo Ameer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Cell nucleus as the most important organelle in eukaryotic cells always attracts the interests from various fields. Although the mechanism has not been fully understood, nuclear morphology plays crucial roles in regulating cell functions.1 Current micro-and nano-engineering techniques enable the control of cell nuclear morphology.2 However, the relationship between nuclear morphology and chromatin structure, as well as cell functions remains unclear. Therefore, in this study, we prepared various micropillar structures which regulated nuclear morphology of human mesenchymal stem cells (hMSCs). We hypothesize that modulation of nuclear morphology via micropillar structures will affect the chromatin compaction and histone modification, which determine the stem cell fate.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages701
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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