TY - GEN
T1 - Influence of nuclear morphology on differentiation of mesenchymal stem cells
AU - Wang, Xinlong
AU - Agrawal, Vasundhara
AU - Duan, Chongwen
AU - Jiang, Bin
AU - Backman, Vadim
AU - Ameer, Guillermo
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Cell nucleus as the most important organelle in eukaryotic cells always attracts the interests from various fields. Although the mechanism has not been fully understood, nuclear morphology plays crucial roles in regulating cell functions.1 Current micro-and nano-engineering techniques enable the control of cell nuclear morphology.2 However, the relationship between nuclear morphology and chromatin structure, as well as cell functions remains unclear. Therefore, in this study, we prepared various micropillar structures which regulated nuclear morphology of human mesenchymal stem cells (hMSCs). We hypothesize that modulation of nuclear morphology via micropillar structures will affect the chromatin compaction and histone modification, which determine the stem cell fate.
AB - Statement of Purpose: Cell nucleus as the most important organelle in eukaryotic cells always attracts the interests from various fields. Although the mechanism has not been fully understood, nuclear morphology plays crucial roles in regulating cell functions.1 Current micro-and nano-engineering techniques enable the control of cell nuclear morphology.2 However, the relationship between nuclear morphology and chromatin structure, as well as cell functions remains unclear. Therefore, in this study, we prepared various micropillar structures which regulated nuclear morphology of human mesenchymal stem cells (hMSCs). We hypothesize that modulation of nuclear morphology via micropillar structures will affect the chromatin compaction and histone modification, which determine the stem cell fate.
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M3 - Conference contribution
AN - SCOPUS:85065422835
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 701
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -