TY - JOUR
T1 - Influence of oncogenic transcription factors on chromatin conformation and implications in prostate cancer
AU - Yang, Yeqing Angela
AU - Kim, Jung
AU - Yu, Jindan
PY - 2014/5/12
Y1 - 2014/5/12
N2 - In recent years, facilitated by rapid technological advances, we are becoming more adept at probing the molecular processes, which take place in the nucleus, that are crucial for the hierarchical regulation and organization of chromatin architecture. With an unprecedented level of resolution, a detailed atlas of chromosomal structures (histone displacement, variants, modifications, chromosome territories, and DNA looping and mechanisms underlying their establishment, provides invaluable insight into physiological as well as pathological phenomena. In this review, we will focus on prostate cancer, a prevalent malignancy in men worldwide, and for which a curative treatment strategy is yet to be attained. We aim to catalog the most frequently observed oncogenic alterations associated with chromatin conformation, while emphasizing the TMPRSS2-ERG fusion, which is found in more than one-half of prostate cancer patients and its functions in compromising the chromatin landscape in prostate cancer.
AB - In recent years, facilitated by rapid technological advances, we are becoming more adept at probing the molecular processes, which take place in the nucleus, that are crucial for the hierarchical regulation and organization of chromatin architecture. With an unprecedented level of resolution, a detailed atlas of chromosomal structures (histone displacement, variants, modifications, chromosome territories, and DNA looping and mechanisms underlying their establishment, provides invaluable insight into physiological as well as pathological phenomena. In this review, we will focus on prostate cancer, a prevalent malignancy in men worldwide, and for which a curative treatment strategy is yet to be attained. We aim to catalog the most frequently observed oncogenic alterations associated with chromatin conformation, while emphasizing the TMPRSS2-ERG fusion, which is found in more than one-half of prostate cancer patients and its functions in compromising the chromatin landscape in prostate cancer.
KW - Chromatin conformation
KW - ERG
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84900545882&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900545882&partnerID=8YFLogxK
U2 - 10.2147/TACG.S35598
DO - 10.2147/TACG.S35598
M3 - Review article
C2 - 24876790
AN - SCOPUS:84900545882
VL - 7
SP - 81
EP - 91
JO - Application of Clinical Genetics
JF - Application of Clinical Genetics
SN - 1178-704X
ER -