Influence of pregnancy on vitiligo activity

Kirsten C. Webb, Sarah Lyon, Beatrice Nardone, Dennis P. West, Roopal V. Kundu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background:Vitiligo vulgaris, an acquired disease related to autoimmune activity directed against melanocytes, is a common disorder of pigmentation affecting up to one percent of the population. Several autoimmune disorders are reported to improve during pregnancy-a state of relative immunosuppression. Objectives: To assess selfreported changes in vitiligo disease activity that occurred during pregnancy. Methods:A survey of 24 subjects with vitiligo was conducted by telephone using questions that pertained to vitiligo history, pregnancy history, and vitiligo disease activity prior to, during, and after pregnancy. Additional questions pertained to demographics, history of other autoimmune disease, and family history of vitiligo. Results: 18 of 24 subjects (75%) reported stable or improvement in vitiligo activity during pregnancy. of these 18 subjects, five (27%) had discontinued vitiligo therapy during their pregnancies. Conclusion: The majority of patients surveyed reported either stable or improved vitiligo activity during pregnancy. These results support a protective effect exerted by the state of pregnancy against changing or progressing depigmentation characteristic of vitiligo vulgaris in the non-pregnant state.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalJournal of Clinical and Aesthetic Dermatology
Issue number12
StatePublished - Dec 2016

ASJC Scopus subject areas

  • Dermatology


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