Influence of serotonin 3A and 3B receptor genes on ciozapine treatment response in schizophrenia

Renan R. Souza; Vincenzo De Luca; Herbert Y. Meltzer; Jeffrey A. Lieberman; James L. Kennedy

doi:10.1097/FPC.0b013e328337ce3e

Influence of serotonin 3A and 3B receptor genes on ciozapine treatment response in schizophrenia

Renan R. Souza, Vincenzo De Luca, Herbert Y. Meltzer, Jeffrey A. Lieberman, James L. Kennedy

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Earlier results suggest a minor role of variants in the serotonin 3 receptor (HTR3) subunit genes on antipsychotic treatment outcome of schizophrenia patients. In this study, we further investigated the role of the subunits A and B of the HTR3 receptor using 140 schizophrenia patients taking clozapine for 6 months. We have found significant allelic association of clozapine response with three variants in the HTR3A receptor (rs2276302, rs1062613, rs1150226) although only rs1062613 association remained significant after permutations (permutated P= 0.041). Moreover, rs2276302 and rs1062613 have shown nominally significant genotypic association. The two haplotypes composed of rs2276302-rs1062613rs1150226 were also nominally significant. Taken together, our results suggest that variants in the HTR3A receptor gene can play a role in the treatment outcome of clozapine in schizophrenia patients that are refractory or intolerant of typical antipsychotic therapy. Further studies are necessary to confirm the reported associations. Pharmacogenetics and Genomics 20:274-276

Original language	English (US)
Pages (from-to)	274-276
Number of pages	3
Journal	Pharmacogenetics and Genomics
Volume	20
Issue number	4
DOIs	https://doi.org/10.1097/FPC.0b013e328337ce3e
State	Published - Apr 1 2010

Keywords

5-HTR3A
5-HTR3B
Antipsychotic
BPRS
Pharmacogenetics
Pharmacogenomics
Response
Serotonin receptor
Treatment outcome

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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title = "Influence of serotonin 3A and 3B receptor genes on ciozapine treatment response in schizophrenia",

abstract = "Earlier results suggest a minor role of variants in the serotonin 3 receptor (HTR3) subunit genes on antipsychotic treatment outcome of schizophrenia patients. In this study, we further investigated the role of the subunits A and B of the HTR3 receptor using 140 schizophrenia patients taking clozapine for 6 months. We have found significant allelic association of clozapine response with three variants in the HTR3A receptor (rs2276302, rs1062613, rs1150226) although only rs1062613 association remained significant after permutations (permutated P= 0.041). Moreover, rs2276302 and rs1062613 have shown nominally significant genotypic association. The two haplotypes composed of rs2276302-rs1062613rs1150226 were also nominally significant. Taken together, our results suggest that variants in the HTR3A receptor gene can play a role in the treatment outcome of clozapine in schizophrenia patients that are refractory or intolerant of typical antipsychotic therapy. Further studies are necessary to confirm the reported associations. Pharmacogenetics and Genomics 20:274-276",

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AU - Kennedy, James L.

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Influence of serotonin 3A and 3B receptor genes on ciozapine treatment response in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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