Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis

Catherine A. Kappel; Roger W. Melvold; Byung S. Kim

doi:10.1016/0165-5728(90)90143-B

Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis

Catherine A. Kappel, Roger W. Melvold, Byung S. Kim^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in certain genotypes derived from C57L/J and SJL/J or SWR/J mice. This is the first report of an animal model for MS that shows an association between sex and susceptibility, and this information may facilitate the investigation of human MS.

Original language	English (US)
Pages (from-to)	15-19
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	29
Issue number	1-3
DOIs	https://doi.org/10.1016/0165-5728(90)90143-B
State	Published - 1990

Keywords

Animal model
Genetics
Multiple sclerosis
Sex influence
Susceptibility
Theiler's virus

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-5728(90)90143-B

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title = "Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis",

abstract = "Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in certain genotypes derived from C57L/J and SJL/J or SWR/J mice. This is the first report of an animal model for MS that shows an association between sex and susceptibility, and this information may facilitate the investigation of human MS.",

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T1 - Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis

AU - Kappel, Catherine A.

AU - Melvold, Roger W.

AU - Kim, Byung S.

PY - 1990

Y1 - 1990

N2 - Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in certain genotypes derived from C57L/J and SJL/J or SWR/J mice. This is the first report of an animal model for MS that shows an association between sex and susceptibility, and this information may facilitate the investigation of human MS.

AB - Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in certain genotypes derived from C57L/J and SJL/J or SWR/J mice. This is the first report of an animal model for MS that shows an association between sex and susceptibility, and this information may facilitate the investigation of human MS.

KW - Animal model

KW - Genetics

KW - Multiple sclerosis

KW - Sex influence

KW - Susceptibility

KW - Theiler's virus

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Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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