Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis

Catherine A. Kappel, Roger W. Melvold, Byung S. Kim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in certain genotypes derived from C57L/J and SJL/J or SWR/J mice. This is the first report of an animal model for MS that shows an association between sex and susceptibility, and this information may facilitate the investigation of human MS.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalJournal of Neuroimmunology
Volume29
Issue number1-3
DOIs
StatePublished - 1990

Keywords

  • Animal model
  • Genetics
  • Multiple sclerosis
  • Sex influence
  • Susceptibility
  • Theiler's virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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