Influence of underfeeding on the spontaneous contraction and on metabolism of labelled arachidonic acid in uteri isolated from intact and ovariectomized rats

S. M. Casalino, J. A. Linares, A. Goldraij*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The effects of restricted diet (50% of the normal intake during 25 days) on the isometric developed tension (IDT), and on the metabolism of labelled arachidonic acid in uteri from intact and spayed (25 days) rats, were studied. Underfeeding produced a fall in the contractile activity of intact rats, while in ovariectomized rats contractile activity increased. Indomethacin reduced uterine contractile activity in all the cases under study. The metabolism of arachidonic acid into different eicosanoids, PGE2, PGF(2α), 6-keto-F(1α), and TXB2, showed that the restricted diet diminished PGE2 and PGF(2α) levels in intact rats, significantly. The reduction in uterine contractile activity and reduced revels of the arachidonic acid metabolites, PGE2 and PGF(2α), were not seen in ovariectomized animals.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume55
Issue number3
DOIs
StatePublished - Sep 1996

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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