The effects of restricted diet (50% of the normal intake during 25 days) on the isometric developed tension (IDT), and on the metabolism of labelled arachidonic acid in uteri from intact and spayed (25 days) rats, were studied. Underfeeding produced a fall in the contractile activity of intact rats, while in ovariectomized rats contractile activity increased. Indomethacin reduced uterine contractile activity in all the cases under study. The metabolism of arachidonic acid into different eicosanoids, PGE2, PGF(2α), 6-keto-F(1α), and TXB2, showed that the restricted diet diminished PGE2 and PGF(2α) levels in intact rats, significantly. The reduction in uterine contractile activity and reduced revels of the arachidonic acid metabolites, PGE2 and PGF(2α), were not seen in ovariectomized animals.
|Original language||English (US)|
|Number of pages||4|
|Journal||Prostaglandins Leukotrienes and Essential Fatty Acids|
|State||Published - Sep 1996|
ASJC Scopus subject areas
- Clinical Biochemistry
- Cell Biology