Influence of voltage-sensitive dendritic conductances on bistable firing and effective synaptic current in cat spinal motoneurons in vivo

R. H. Lee, C. J. Heckman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

1. After application of the noradrenergic α1 agonist methoxamine, muscle spindle Ia input evoked bistable firing patterns (i.e., persistent discharges after Ia input ceased) in adult spinal motoneurons in the decerebrate cat preparation. These bistable discharge patterns were compared with the Ia currents generated in voltage-clamp conditions. 2. During voltage clamp at depolarized holding potentials, the Ia effective synaptic current underwent strong amplification. In those cells with strong bistable firing, a prolonged tail current followed the Ia input. Because the voltage clamp held the behavior of somatic conductances constant, these data indicate that voltage-sensitive conductances in the motoneuron dendrites made an important contribution to bistable firing.

Original languageEnglish (US)
Pages (from-to)2107-2110
Number of pages4
JournalJournal of neurophysiology
Volume76
Issue number3
DOIs
StatePublished - Sep 1996

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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