Influences of nanocarrier morphology on therapeutic immunomodulation

Molly Frey, Sharan Bobbala, Nicholas Karabin, Evan Scott*

*Corresponding author for this work

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Nanomaterials provide numerous advantages for the administration of therapeutics, particularly as carriers of immunomodulatory agents targeting specific immune cell populations during immunotherapy. While the physicochemical characteristics of nanocarriers have long been linked to their therapeutic efficacy and applications, focus has primarily been placed on assessing influences of size and surface chemistry. In addition to these materials properties, the nanostructure morphology, in other words, shape and aspect ratio, has emerged as an equally important feature of nanocarriers that can dictate mechanisms of endocytosis, biodistribution and degree of cytotoxicity. In this review, we will highlight how the morphological features of nanostructures influence the immune responses elicited during therapeutic immunomodulation.

Original languageEnglish (US)
Pages (from-to)1795-1811
Number of pages17
JournalNanomedicine
Volume13
Issue number14
DOIs
StatePublished - Jan 1 2018

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Keywords

  • antigen-presenting cells
  • biodistribution
  • drug delivery
  • immunomodulation
  • immunotherapy
  • nanocarrier
  • nanomaterial
  • nanoparticle
  • theranostics
  • vaccination

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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