Influenza virus proton channels

Lawrence H. Pinto*, Robert A. Lamb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The M2 ion channel proteins of influenza A and B viruses are essential to viral replication. The two ion channels share a common motif, HXXXW, that is responsible for proton selectivity and activation. The ion channel for the influenza A virus, but not influenza B virus, is inhibited by the antiviral drug amantadine and amantadine-resistant escape mutants form in treated influenza A patients. The studies reviewed suggest that an antiviral compound directed against the conserved motif would be more useful than amantadine in inhibiting viral replication.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalPhotochemical and Photobiological Sciences
Volume5
Issue number6
DOIs
StatePublished - Jun 7 2006

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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