Information maximizing component analysis of left ventricular remodeling due to myocardial infarction

Xingyu Zhang, Bharath Ambale-Venkatesh, David A. Bluemke, Brett R. Cowan, J. Paul Finn, Alan H. Kadish, Daniel C. Lee, Joao A C Lima, William G. Hundley, Avan Suinesiaputra, Alistair A. Young, Pau Medrano-Gracia*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: Although adverse left ventricular shape changes (remodeling) after myocardial infarction (MI) are predictive of morbidity and mortality, current clinical assessment is limited to simple mass and volume measures, or dimension ratios such as length to width ratio. We hypothesized that information maximizing component analysis (IMCA), a supervised feature extraction method, can provide more efficient and sensitive indices of overall remodeling. Methods: IMCA was compared to linear discriminant analysis (LDA), both supervised methods, to extract the most discriminatory global shape changes associated with remodeling after MI. Finite element shape models from 300 patients with myocardial infarction from the DETERMINE study (age 31-86, mean age 63, 20% women) were compared with 1991 asymptomatic cases from the MESA study (age 44-84, mean age 62, 52% women) available from the Cardiac Atlas Project. IMCA and LDA were each used to identify a single mode of global remodeling best discriminating the two groups. Logistic regression was employed to determine the association between the remodeling index and MI. Goodness-of-fit results were compared against a baseline logistic model comprising standard clinical indices. Results: A single IMCA mode simultaneously describing end-diastolic and end-systolic shapes achieved best results (lowest Deviance, Akaike information criterionand Bayesian information criterion, and the largest area under thereceiver-operating-characteristiccurve). This mode provided a continuous scale where remodeling can be quantified and visualized, showing that MI patients tend to present larger size and more spherical shape, more bulging of the apex, and thinner wall thickness. Conclusions: IMCA enables better characterization of global remodeling than LDA, and can be used to quantify progression of disease and the effect of treatment. These data and results are available from the Cardiac Atlas Project ( ).

Original languageEnglish (US)
Article number343
JournalJournal of Translational Medicine
Issue number1
StatePublished - Nov 3 2015


  • Cardiac remodeling
  • Information maximizing component analysis
  • Linear discriminant analysis
  • Logistic regression
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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