Infragranular barrel cortex activity is enhanced with learning

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The barrel cortex (BC) is essential for the acquisition of whiskersignaled trace eyeblink conditioning and shows learning-related expansion of the trained barrels after the acquisition of a whiskersignaled task. Most previous research examining the role of the BC in learning has focused on anatomic changes in the layer IV representation of the cortical barrels. We studied single-unit extracellular recordings from individual neurons in layers V and VI of the BC as rabbits acquired the whisker-signaled trace eyeblink conditioning task. Neurons in layers V and VI in both conditioned and pseudoconditioned animals robustly responded to whisker stimulation, but neurons in conditioned animals showed a significant enhancement in responsiveness in concert with learning. Learning-related changes in firing rate occurred as early as the day of learning criterion within the infra granular layers of the primary sensory cortex.

Original languageEnglish (US)
Pages (from-to)1278-1287
Number of pages10
JournalJournal of neurophysiology
Volume108
Issue number5
DOIs
StatePublished - Sep 1 2012

Fingerprint

Learning
Vibrissae
Neurons
Rabbits
Research
Conditioning (Psychology)

Keywords

  • Associative learning
  • Classical conditioning
  • Somatosensory cortex
  • Trace eyeblink conditioning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

@article{904d5623137f48c58a1fdff62fe23bda,
title = "Infragranular barrel cortex activity is enhanced with learning",
abstract = "The barrel cortex (BC) is essential for the acquisition of whiskersignaled trace eyeblink conditioning and shows learning-related expansion of the trained barrels after the acquisition of a whiskersignaled task. Most previous research examining the role of the BC in learning has focused on anatomic changes in the layer IV representation of the cortical barrels. We studied single-unit extracellular recordings from individual neurons in layers V and VI of the BC as rabbits acquired the whisker-signaled trace eyeblink conditioning task. Neurons in layers V and VI in both conditioned and pseudoconditioned animals robustly responded to whisker stimulation, but neurons in conditioned animals showed a significant enhancement in responsiveness in concert with learning. Learning-related changes in firing rate occurred as early as the day of learning criterion within the infra granular layers of the primary sensory cortex.",
keywords = "Associative learning, Classical conditioning, Somatosensory cortex, Trace eyeblink conditioning",
author = "Ward, {Rebekah L.} and Flores, {Luke C.} and Disterhoft, {John F}",
year = "2012",
month = "9",
day = "1",
doi = "10.1152/jn.00305.2012",
language = "English (US)",
volume = "108",
pages = "1278--1287",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "5",

}

Infragranular barrel cortex activity is enhanced with learning. / Ward, Rebekah L.; Flores, Luke C.; Disterhoft, John F.

In: Journal of neurophysiology, Vol. 108, No. 5, 01.09.2012, p. 1278-1287.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Infragranular barrel cortex activity is enhanced with learning

AU - Ward, Rebekah L.

AU - Flores, Luke C.

AU - Disterhoft, John F

PY - 2012/9/1

Y1 - 2012/9/1

N2 - The barrel cortex (BC) is essential for the acquisition of whiskersignaled trace eyeblink conditioning and shows learning-related expansion of the trained barrels after the acquisition of a whiskersignaled task. Most previous research examining the role of the BC in learning has focused on anatomic changes in the layer IV representation of the cortical barrels. We studied single-unit extracellular recordings from individual neurons in layers V and VI of the BC as rabbits acquired the whisker-signaled trace eyeblink conditioning task. Neurons in layers V and VI in both conditioned and pseudoconditioned animals robustly responded to whisker stimulation, but neurons in conditioned animals showed a significant enhancement in responsiveness in concert with learning. Learning-related changes in firing rate occurred as early as the day of learning criterion within the infra granular layers of the primary sensory cortex.

AB - The barrel cortex (BC) is essential for the acquisition of whiskersignaled trace eyeblink conditioning and shows learning-related expansion of the trained barrels after the acquisition of a whiskersignaled task. Most previous research examining the role of the BC in learning has focused on anatomic changes in the layer IV representation of the cortical barrels. We studied single-unit extracellular recordings from individual neurons in layers V and VI of the BC as rabbits acquired the whisker-signaled trace eyeblink conditioning task. Neurons in layers V and VI in both conditioned and pseudoconditioned animals robustly responded to whisker stimulation, but neurons in conditioned animals showed a significant enhancement in responsiveness in concert with learning. Learning-related changes in firing rate occurred as early as the day of learning criterion within the infra granular layers of the primary sensory cortex.

KW - Associative learning

KW - Classical conditioning

KW - Somatosensory cortex

KW - Trace eyeblink conditioning

UR - http://www.scopus.com/inward/record.url?scp=84865833164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865833164&partnerID=8YFLogxK

U2 - 10.1152/jn.00305.2012

DO - 10.1152/jn.00305.2012

M3 - Article

C2 - 22696544

AN - SCOPUS:84865833164

VL - 108

SP - 1278

EP - 1287

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 5

ER -