Inhabitary effects of pamidronate made in China on osteoclastic bone resorption in vitro

Y. Yang*, Zhi-Dong Ge, A. W. Zhou, M. Z. Chen, Z. K. Leng, R. J. Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

To study the effects of Pamidronate (APD) made in China and Bonefos (CL2MDP, as positive control drug) on osteoclastic bone resorbing lacunae by means of culturing osteocasts on slices, the techniques of photomicrography, microdensitometric scan and computer image analysis. The results indicated that APD (5, 50 or 500 μmol · L-1) caused dose-dependent reduction in the numbers of osteoclastic bone resorbing lacunae. The suppression by the lowest effective, concentration of APD (5 μmol · L-1) was more remarkable than that of CL2MDP. Both APD and CL2MDP reduced the surface areas of osteoclastic bone resorbing lacunae. It is suggested that APD could directly suppress osteoclastic bone resorption and might be effective in osteoporosis.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalChinese Pharmacological Bulletin
Volume13
Issue number2
StatePublished - 1997

Keywords

  • Bone resorption
  • Osteoclasts
  • Pamidronate

ASJC Scopus subject areas

  • Pharmacology

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