Inhabitary effects of pamidronate made in China on osteoclastic bone resorption in vitro

Y. Yang; Zhi-Dong Ge; A. W. Zhou; M. Z. Chen; Z. K. Leng; R. J. Zhang

Inhabitary effects of pamidronate made in China on osteoclastic bone resorption in vitro

Y. Yang^*, Zhi-Dong Ge, A. W. Zhou, M. Z. Chen, Z. K. Leng, R. J. Zhang

^*Corresponding author for this work

Pediatrics

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Abstract

To study the effects of Pamidronate (APD) made in China and Bonefos (CL₂MDP, as positive control drug) on osteoclastic bone resorbing lacunae by means of culturing osteocasts on slices, the techniques of photomicrography, microdensitometric scan and computer image analysis. The results indicated that APD (5, 50 or 500 μmol · L^-1) caused dose-dependent reduction in the numbers of osteoclastic bone resorbing lacunae. The suppression by the lowest effective, concentration of APD (5 μmol · L^-1) was more remarkable than that of CL₂MDP. Both APD and CL₂MDP reduced the surface areas of osteoclastic bone resorbing lacunae. It is suggested that APD could directly suppress osteoclastic bone resorption and might be effective in osteoporosis.

Original language	English (US)
Pages (from-to)	141-143
Number of pages	3
Journal	Chinese Pharmacological Bulletin
Volume	13
Issue number	2
State	Published - 1997

Keywords

Bone resorption
Osteoclasts
Pamidronate

ASJC Scopus subject areas

Pharmacology

Cite this

@article{76e3c608dde844cda0a898ae824b0800,

title = "Inhabitary effects of pamidronate made in China on osteoclastic bone resorption in vitro",

abstract = "To study the effects of Pamidronate (APD) made in China and Bonefos (CL2MDP, as positive control drug) on osteoclastic bone resorbing lacunae by means of culturing osteocasts on slices, the techniques of photomicrography, microdensitometric scan and computer image analysis. The results indicated that APD (5, 50 or 500 μmol · L-1) caused dose-dependent reduction in the numbers of osteoclastic bone resorbing lacunae. The suppression by the lowest effective, concentration of APD (5 μmol · L-1) was more remarkable than that of CL2MDP. Both APD and CL2MDP reduced the surface areas of osteoclastic bone resorbing lacunae. It is suggested that APD could directly suppress osteoclastic bone resorption and might be effective in osteoporosis.",

keywords = "Bone resorption, Osteoclasts, Pamidronate",

author = "Y. Yang and Zhi-Dong Ge and Zhou, {A. W.} and Chen, {M. Z.} and Leng, {Z. K.} and Zhang, {R. J.}",

year = "1997",

language = "English (US)",

volume = "13",

pages = "141--143",

journal = "Chinese Pharmacological Bulletin",

issn = "1001-1978",

publisher = "Institute of Clinical Pharmacology",

number = "2",

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TY - JOUR

T1 - Inhabitary effects of pamidronate made in China on osteoclastic bone resorption in vitro

AU - Yang, Y.

AU - Ge, Zhi-Dong

AU - Zhou, A. W.

AU - Chen, M. Z.

AU - Leng, Z. K.

AU - Zhang, R. J.

PY - 1997

Y1 - 1997

N2 - To study the effects of Pamidronate (APD) made in China and Bonefos (CL2MDP, as positive control drug) on osteoclastic bone resorbing lacunae by means of culturing osteocasts on slices, the techniques of photomicrography, microdensitometric scan and computer image analysis. The results indicated that APD (5, 50 or 500 μmol · L-1) caused dose-dependent reduction in the numbers of osteoclastic bone resorbing lacunae. The suppression by the lowest effective, concentration of APD (5 μmol · L-1) was more remarkable than that of CL2MDP. Both APD and CL2MDP reduced the surface areas of osteoclastic bone resorbing lacunae. It is suggested that APD could directly suppress osteoclastic bone resorption and might be effective in osteoporosis.

AB - To study the effects of Pamidronate (APD) made in China and Bonefos (CL2MDP, as positive control drug) on osteoclastic bone resorbing lacunae by means of culturing osteocasts on slices, the techniques of photomicrography, microdensitometric scan and computer image analysis. The results indicated that APD (5, 50 or 500 μmol · L-1) caused dose-dependent reduction in the numbers of osteoclastic bone resorbing lacunae. The suppression by the lowest effective, concentration of APD (5 μmol · L-1) was more remarkable than that of CL2MDP. Both APD and CL2MDP reduced the surface areas of osteoclastic bone resorbing lacunae. It is suggested that APD could directly suppress osteoclastic bone resorption and might be effective in osteoporosis.

KW - Bone resorption

KW - Osteoclasts

KW - Pamidronate

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M3 - Article

AN - SCOPUS:0030752912

SN - 1001-1978

VL - 13

SP - 141

EP - 143

JO - Chinese Pharmacological Bulletin

JF - Chinese Pharmacological Bulletin

IS - 2

ER -

Inhabitary effects of pamidronate made in China on osteoclastic bone resorption in vitro

Abstract

Keywords

ASJC Scopus subject areas

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