Abstract
Halothane: a halogenated alkane compound that is a potent bronchodilator with very little pungency. For these reasons, it is extremely useful for inhalational inductions in children. Its MAC is 0.75 and its blood/gas partition coefficient is 2.4. It has the highest level of metabolization by the liver of any of the volatile anesthetics. The major metabolite is trifluoroacetic acid (TFA) and an immune-mediated reaction to this is the likely culprit for the hepatotoxicity that sometimes results, i.e., “halothane hepatitis.”
| Original language | English (US) |
|---|---|
| Title of host publication | Essential Clinical Anesthesia Review |
| Subtitle of host publication | Keywords, Questions and Answers for the Boards |
| Publisher | Cambridge University Press |
| Pages | 115-117 |
| Number of pages | 3 |
| ISBN (Electronic) | 9781139584005 |
| ISBN (Print) | 9781107681309 |
| DOIs | |
| State | Published - Jan 1 2015 |
Keywords
- Altitude changes and vaporizer output
- CO production
- Changing vaporizers and vapor pressure
- Compound A
- Contraindications to nitrous oxide
- Desflurane
- Halothane
- Isoflurane
- Malignant hyperthermia
- Nitrous oxide
- Sevoflurane
- Tec6 vaporizer
ASJC Scopus subject areas
- Medicine(all)
