Inhaled corticosteroids and augmented bronchodilator responsiveness in Latino and African American asthmatic patients

Mariam Naqvi, Haig Tcheurekdjian, Julie A. DeBoard, L. Keoki Williams, Daniel Navarro, Richard A. Castro, Jose R. Rodriguez-Santana, Rocio Chapela, H. Geoffrey Watson, Kelley Meade, William Rodriguez-Cintron, Michael LeNoir, Shannon M. Thyne, Pedro C. Avila, Shweta Choudhry, Esteban González Burchard

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Background: National asthma guidelines recommend that patients with persistent asthma regularly use an inhaled corticosteroid (ICS) in addition to as-needed albuterol, yet recent debates question whether this combination is equally efficacious in all ethnicities. Objective: To examine the effect of ICS use on bronchodilator responsiveness to albuterol in 3 different ethnic populations. Methods: A cross-sectional study of 106 Mexican Americans, 246 Puerto Ricans, and 163 African Americans with physician-diagnosed persistent asthma. Asthma severity, ethnicity, and medication use were evaluated using spirometry and questionnaires. Percentage change in forced expiratory volume in 1 second (FEV1) was compared in patients who used ICSs vs those who used a short-acting β2-agonist as their only asthma medication. Results: Inhaled corticosteroid use was associated with improvements in the percentage change in FEV1 after albuterol administration in Mexican Americans (21.7%, P = .01) and Puerto Ricans (18.5%, P = .02) but not in African Americans (3.0%, P = .73). Conclusions: Inhaled corticosteroid use is associated with augmented bronchodilator responsiveness to albuterol in Mexican Americans and Puerto Ricans, but not in African Americans, with persistent asthma. This underscores the need for an improved understanding of ethnic-specific drug-drug interactions, particularly in those subgroups experiencing the highest burden of asthma morbidity and mortality in the United States.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalAnnals of Allergy, Asthma and Immunology
Volume100
Issue number6
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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    Naqvi, M., Tcheurekdjian, H., DeBoard, J. A., Williams, L. K., Navarro, D., Castro, R. A., Rodriguez-Santana, J. R., Chapela, R., Watson, H. G., Meade, K., Rodriguez-Cintron, W., LeNoir, M., Thyne, S. M., Avila, P. C., Choudhry, S., & Burchard, E. G. (2008). Inhaled corticosteroids and augmented bronchodilator responsiveness in Latino and African American asthmatic patients. Annals of Allergy, Asthma and Immunology, 100(6), 551-557. https://doi.org/10.1016/S1081-1206(10)60055-5