Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide

Lisa K. Kelly; Nicolas F.M. Porta; Denise M. Goodman; Christopher L. Carroll; Robin H. Steinhorn

doi:10.1067/mpd.2002.129849

Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide

Lisa K. Kelly, Nicolas F.M. Porta, Denise M. Goodman, Christopher L. Carroll, Robin H. Steinhorn^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

We report the use of inhaled prostacyclin (PGI₂) in 4 neonates with persistent pulmonary hypertension and hypoxemia refractory to inhaled nitric oxide. Oxygenation rapidly improved after inhalation of PGI₂ in all infants. The condition of one infant subsequently deteriorated, and alveolar capillary dysplasia was found at autopsy. The surviving infants were discharged with normal oxygen saturations in room air.

Original language	English (US)
Pages (from-to)	830-832
Number of pages	3
Journal	journal of pediatrics
Volume	141
Issue number	6
DOIs	https://doi.org/10.1067/mpd.2002.129849
State	Published - Dec 1 2002

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1067/mpd.2002.129849

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abstract = "We report the use of inhaled prostacyclin (PGI2) in 4 neonates with persistent pulmonary hypertension and hypoxemia refractory to inhaled nitric oxide. Oxygenation rapidly improved after inhalation of PGI2 in all infants. The condition of one infant subsequently deteriorated, and alveolar capillary dysplasia was found at autopsy. The surviving infants were discharged with normal oxygen saturations in room air.",

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AU - Carroll, Christopher L.

AU - Steinhorn, Robin H.

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N2 - We report the use of inhaled prostacyclin (PGI2) in 4 neonates with persistent pulmonary hypertension and hypoxemia refractory to inhaled nitric oxide. Oxygenation rapidly improved after inhalation of PGI2 in all infants. The condition of one infant subsequently deteriorated, and alveolar capillary dysplasia was found at autopsy. The surviving infants were discharged with normal oxygen saturations in room air.

AB - We report the use of inhaled prostacyclin (PGI2) in 4 neonates with persistent pulmonary hypertension and hypoxemia refractory to inhaled nitric oxide. Oxygenation rapidly improved after inhalation of PGI2 in all infants. The condition of one infant subsequently deteriorated, and alveolar capillary dysplasia was found at autopsy. The surviving infants were discharged with normal oxygen saturations in room air.

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Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide

Abstract

ASJC Scopus subject areas

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