Inhibin: Actions and signalling

David J. Phillips; Teresa K. Woodruff

doi:10.1080/08977190410001688687

Inhibin: Actions and signalling

David J. Phillips^*, Teresa K. Woodruff

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Short survey › peer-review

40 Scopus citations

Abstract

Inhibin is best known as a reproductive hormone that inhibits release of follicle-stimulating hormone (FSH) from the pituitary gland. Over the last decade or so a number of other biological roles have emerged, putting inhibin more in the class of a growth factor. Despite this, little is known of the signalling pathways for this protein. This minireview summarises the pertinent aspects of inhibin biology and focuses on four potential signalling mechanisms through which inhibin might influence cellular function, namely subunit availability, receptor assembly, co-receptors and signalling through inhibin-specific signalling pathways.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	Growth Factors
Volume	22
Issue number	1
DOIs	https://doi.org/10.1080/08977190410001688687
State	Published - Mar 2004

Funding

DJP is supported by a Program Grant (1143786) of the NHMRC of Australia. TKW is supported by the National Institutes of Health grants HD037096 and HD041857.

Keywords

Activin
Betaglycan
Inhibin
Transforming growth factor-β

ASJC Scopus subject areas

Endocrinology
Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/08977190410001688687

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title = "Inhibin: Actions and signalling",

abstract = "Inhibin is best known as a reproductive hormone that inhibits release of follicle-stimulating hormone (FSH) from the pituitary gland. Over the last decade or so a number of other biological roles have emerged, putting inhibin more in the class of a growth factor. Despite this, little is known of the signalling pathways for this protein. This minireview summarises the pertinent aspects of inhibin biology and focuses on four potential signalling mechanisms through which inhibin might influence cellular function, namely subunit availability, receptor assembly, co-receptors and signalling through inhibin-specific signalling pathways.",

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AU - Phillips, David J.

AU - Woodruff, Teresa K.

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AB - Inhibin is best known as a reproductive hormone that inhibits release of follicle-stimulating hormone (FSH) from the pituitary gland. Over the last decade or so a number of other biological roles have emerged, putting inhibin more in the class of a growth factor. Despite this, little is known of the signalling pathways for this protein. This minireview summarises the pertinent aspects of inhibin biology and focuses on four potential signalling mechanisms through which inhibin might influence cellular function, namely subunit availability, receptor assembly, co-receptors and signalling through inhibin-specific signalling pathways.

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KW - Betaglycan

KW - Inhibin

KW - Transforming growth factor-β

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Inhibin: Actions and signalling

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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