Inhibin and activin. Molecular aspects of regulation and function

Kelly Edward Mayo*

*Corresponding author for this work

Research output: Contribution to journalShort survey

44 Citations (Scopus)

Abstract

Inhibins and activins exhibit a broad spectrum of biologic activities, many of which affect the reproductive axis. Within the ovary and testis, the synthesis of the inhibin and activin α and β subunits is regulated by circulating hormones, such as the pituitary gonadotropins, and by diverse paracrine factors. Considerable progress has been made in establishing patterns of inhibin and activin subunit gene expression in the gonads and in cultured gonadal cells. Analysis of the inhibin and activin subunit genes is now providing insight into the signaling pathways and molecular mechanisms by which inhibin and activin subunit gene expression is modulated in the ovary and testis. Genetic manipulation of the inhibin and activin subunit genes promises additional revelations on the biologic functions of these intriguing hormones.

Original languageEnglish (US)
Pages (from-to)407-415
Number of pages9
JournalTrends in Endocrinology and Metabolism
Volume5
Issue number10
DOIs
StatePublished - Jan 1 1994

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Activins
Inhibins
Testis
Ovary
Hormones
Pituitary Gonadotropins
Gene Expression
Gonads
Genes
Cultured Cells

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

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Inhibin and activin. Molecular aspects of regulation and function. / Mayo, Kelly Edward.

In: Trends in Endocrinology and Metabolism, Vol. 5, No. 10, 01.01.1994, p. 407-415.

Research output: Contribution to journalShort survey

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AB - Inhibins and activins exhibit a broad spectrum of biologic activities, many of which affect the reproductive axis. Within the ovary and testis, the synthesis of the inhibin and activin α and β subunits is regulated by circulating hormones, such as the pituitary gonadotropins, and by diverse paracrine factors. Considerable progress has been made in establishing patterns of inhibin and activin subunit gene expression in the gonads and in cultured gonadal cells. Analysis of the inhibin and activin subunit genes is now providing insight into the signaling pathways and molecular mechanisms by which inhibin and activin subunit gene expression is modulated in the ovary and testis. Genetic manipulation of the inhibin and activin subunit genes promises additional revelations on the biologic functions of these intriguing hormones.

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