Inhibin at 90

From discovery to clinical application, a historical review

Yogeshwar Makanji, Jie Zhu, Rama K Mishra, Chris Holmquist, Winifred P.S. Wong, Neena B. Schwartz, Kelly Edward Mayo, Teresa K Woodruff*

*Corresponding author for this work

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years later, whatweknow about inhibin stretches far beyond its well-established capacity to inhibit activin signaling and suppress pituitary FSH production. Inhibin is one of the major reproductive hormones involved in the regulation of folliculogenesis and steroidogenesis. Although the physiological role of inhibin as an activin antagonist in other organ systems is not as well defined as it is in the pituitary-gonadal axis, inhibin also modulates biological processes in other organs through paracrine, autocrine, and/or endocrine mechanisms. Inhibin and components of its signaling pathway are expressed in many organs. Diagnostically, inhibin is used for prenatal screening of Down syndrome as part of the quadruple test and as a biochemical marker in the assessment of ovarian reserve. In this review, we provide a comprehensive summary of our current understanding of the biological role of inhibin, its relationship with activin, its signaling mechanisms, and its potential value as a diagnostic marker for reproductive function and pregnancy-associated conditions.

Original languageEnglish (US)
Pages (from-to)747-794
Number of pages48
JournalEndocrine reviews
Volume35
Issue number5
DOIs
StatePublished - Jan 1 2014

Fingerprint

Inhibins
Activins
Pituitary Hormone-Releasing Hormones
Biological Phenomena
Pituitary Hormones
Down Syndrome
Prenatal Diagnosis
Biomarkers
Hormones
Pregnancy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Makanji, Yogeshwar ; Zhu, Jie ; Mishra, Rama K ; Holmquist, Chris ; Wong, Winifred P.S. ; Schwartz, Neena B. ; Mayo, Kelly Edward ; Woodruff, Teresa K. / Inhibin at 90 : From discovery to clinical application, a historical review. In: Endocrine reviews. 2014 ; Vol. 35, No. 5. pp. 747-794.
@article{d2b176c4ca854013bf758ef11b8c0560,
title = "Inhibin at 90: From discovery to clinical application, a historical review",
abstract = "When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years later, whatweknow about inhibin stretches far beyond its well-established capacity to inhibit activin signaling and suppress pituitary FSH production. Inhibin is one of the major reproductive hormones involved in the regulation of folliculogenesis and steroidogenesis. Although the physiological role of inhibin as an activin antagonist in other organ systems is not as well defined as it is in the pituitary-gonadal axis, inhibin also modulates biological processes in other organs through paracrine, autocrine, and/or endocrine mechanisms. Inhibin and components of its signaling pathway are expressed in many organs. Diagnostically, inhibin is used for prenatal screening of Down syndrome as part of the quadruple test and as a biochemical marker in the assessment of ovarian reserve. In this review, we provide a comprehensive summary of our current understanding of the biological role of inhibin, its relationship with activin, its signaling mechanisms, and its potential value as a diagnostic marker for reproductive function and pregnancy-associated conditions.",
author = "Yogeshwar Makanji and Jie Zhu and Mishra, {Rama K} and Chris Holmquist and Wong, {Winifred P.S.} and Schwartz, {Neena B.} and Mayo, {Kelly Edward} and Woodruff, {Teresa K}",
year = "2014",
month = "1",
day = "1",
doi = "10.1210/er.2014-1003",
language = "English (US)",
volume = "35",
pages = "747--794",
journal = "Endocrine Reviews",
issn = "0163-769X",
publisher = "The Endocrine Society",
number = "5",

}

Inhibin at 90 : From discovery to clinical application, a historical review. / Makanji, Yogeshwar; Zhu, Jie; Mishra, Rama K; Holmquist, Chris; Wong, Winifred P.S.; Schwartz, Neena B.; Mayo, Kelly Edward; Woodruff, Teresa K.

In: Endocrine reviews, Vol. 35, No. 5, 01.01.2014, p. 747-794.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Inhibin at 90

T2 - From discovery to clinical application, a historical review

AU - Makanji, Yogeshwar

AU - Zhu, Jie

AU - Mishra, Rama K

AU - Holmquist, Chris

AU - Wong, Winifred P.S.

AU - Schwartz, Neena B.

AU - Mayo, Kelly Edward

AU - Woodruff, Teresa K

PY - 2014/1/1

Y1 - 2014/1/1

N2 - When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years later, whatweknow about inhibin stretches far beyond its well-established capacity to inhibit activin signaling and suppress pituitary FSH production. Inhibin is one of the major reproductive hormones involved in the regulation of folliculogenesis and steroidogenesis. Although the physiological role of inhibin as an activin antagonist in other organ systems is not as well defined as it is in the pituitary-gonadal axis, inhibin also modulates biological processes in other organs through paracrine, autocrine, and/or endocrine mechanisms. Inhibin and components of its signaling pathway are expressed in many organs. Diagnostically, inhibin is used for prenatal screening of Down syndrome as part of the quadruple test and as a biochemical marker in the assessment of ovarian reserve. In this review, we provide a comprehensive summary of our current understanding of the biological role of inhibin, its relationship with activin, its signaling mechanisms, and its potential value as a diagnostic marker for reproductive function and pregnancy-associated conditions.

AB - When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years later, whatweknow about inhibin stretches far beyond its well-established capacity to inhibit activin signaling and suppress pituitary FSH production. Inhibin is one of the major reproductive hormones involved in the regulation of folliculogenesis and steroidogenesis. Although the physiological role of inhibin as an activin antagonist in other organ systems is not as well defined as it is in the pituitary-gonadal axis, inhibin also modulates biological processes in other organs through paracrine, autocrine, and/or endocrine mechanisms. Inhibin and components of its signaling pathway are expressed in many organs. Diagnostically, inhibin is used for prenatal screening of Down syndrome as part of the quadruple test and as a biochemical marker in the assessment of ovarian reserve. In this review, we provide a comprehensive summary of our current understanding of the biological role of inhibin, its relationship with activin, its signaling mechanisms, and its potential value as a diagnostic marker for reproductive function and pregnancy-associated conditions.

UR - http://www.scopus.com/inward/record.url?scp=84908323917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908323917&partnerID=8YFLogxK

U2 - 10.1210/er.2014-1003

DO - 10.1210/er.2014-1003

M3 - Review article

VL - 35

SP - 747

EP - 794

JO - Endocrine Reviews

JF - Endocrine Reviews

SN - 0163-769X

IS - 5

ER -