Inhibit globally, act locally: CDK7 inhibitors in cancer therapy

Kaixiang Cao, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalShort survey

16 Scopus citations

Abstract

Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. Recently, Kwiatkowski and colleagues identified a novel CDK7-specific inhibitor, THZ1, that hinders proliferation in cancer cell lines and dampens global transcription in Tcell leukemia.

Original languageEnglish (US)
Pages (from-to)158-159
Number of pages2
JournalCancer Cell
Volume26
Issue number2
DOIs
StatePublished - Aug 11 2014

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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