Inhibit globally, act locally: CDK7 inhibitors in cancer therapy

Kaixiang Cao; Ali Shilatifard

doi:10.1016/j.ccr.2014.07.020

Inhibit globally, act locally: CDK7 inhibitors in cancer therapy

Kaixiang Cao, Ali Shilatifard^*

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

27 Scopus citations

Abstract

Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. Recently, Kwiatkowski and colleagues identified a novel CDK7-specific inhibitor, THZ1, that hinders proliferation in cancer cell lines and dampens global transcription in Tcell leukemia.

Original language	English (US)
Pages (from-to)	158-159
Number of pages	2
Journal	Cancer cell
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.ccr.2014.07.020
State	Published - Aug 11 2014

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2014.07.020

Cite this

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title = "Inhibit globally, act locally: CDK7 inhibitors in cancer therapy",

abstract = "Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. Recently, Kwiatkowski and colleagues identified a novel CDK7-specific inhibitor, THZ1, that hinders proliferation in cancer cell lines and dampens global transcription in Tcell leukemia.",

author = "Kaixiang Cao and Ali Shilatifard",

year = "2014",

month = aug,

day = "11",

doi = "10.1016/j.ccr.2014.07.020",

language = "English (US)",

volume = "26",

pages = "158--159",

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number = "2",

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TY - JOUR

T1 - Inhibit globally, act locally

T2 - CDK7 inhibitors in cancer therapy

AU - Cao, Kaixiang

AU - Shilatifard, Ali

PY - 2014/8/11

Y1 - 2014/8/11

N2 - Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. Recently, Kwiatkowski and colleagues identified a novel CDK7-specific inhibitor, THZ1, that hinders proliferation in cancer cell lines and dampens global transcription in Tcell leukemia.

AB - Cyclin-dependent kinases (CDKs) are involved in temporal control of the cell cycle and transcription and play central roles in cancer development and metastasis. Recently, Kwiatkowski and colleagues identified a novel CDK7-specific inhibitor, THZ1, that hinders proliferation in cancer cell lines and dampens global transcription in Tcell leukemia.

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U2 - 10.1016/j.ccr.2014.07.020

DO - 10.1016/j.ccr.2014.07.020

M3 - Short survey

C2 - 25117707

AN - SCOPUS:84905709099

SN - 1535-6108

VL - 26

SP - 158

EP - 159

JO - Cancer cell

JF - Cancer cell

IS - 2

ER -

Inhibit globally, act locally: CDK7 inhibitors in cancer therapy

Abstract

ASJC Scopus subject areas

UN SDGs

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