Inhibiting MNKs promote macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity

Keyphrases

• Macrophages 100%
• Tumor Immunity 100%
• CD8+ T Cells 100%
• Mnk Inhibitors 100%
• Tumor-associated Macrophages 60%
• Pancreatic Tumor 60%
• Tumor 40%
• Thyroid Tumor 40%
• Tumor Growth 20%
• Antitumor Activity 20%
• Programmed Death-ligand 1 (PD-L1) 20%
• Anti-tumor Response 20%
• Tumor Microenvironment 20%
• Synergize 20%
• Infiltration 20%
• CD8+ T Cell Exhaustion 20%
• Antitumor Immune Response 20%
• Immunosuppressive Microenvironment 20%
• Effector Function 20%
• Combination Regimen 20%
• Inhibitor Treatment 20%
• CD8+ T Cell Infiltration 20%
• Animal Survival 20%
• T Cell Exhaustion 20%
• Macrophage Depletion 20%
• Immunosuppressive Tumor 20%
• Anti-PD-1 Antibody 20%
• Antibody-associated 20%
• Tumor Slice Cultures 20%

Immunology and Microbiology

• Immunosuppressive Drug 100%
• Cytotoxic T-Cell 100%
• Macrophage 100%
• Tumor-Associated Macrophage 50%
• Thyroid 33%
• Immune Response 16%
• Cell Death 16%
• Upregulation 16%
• Cell Infiltration 16%
• Antineoplastic Activity 16%
• Slice Culture 16%
• T Cell 16%
• Immunology 16%