Inhibition by chondroitin sulfate e can specify functional Wnt/β-catenin signaling thresholds in NIH3T3 fibroblasts

Catherine M. Willis, Michael Klüppel*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Wnt/β-catenin signaling is a therapeutic target in cancer and other diseases but also has important physiological functions. Results: CS-E can inhibit Wnt/β-catenin signaling and interfere with selective transcriptional and biological outcomes. Conclusion: Wnt/β-catenin signaling thresholds control distinct downstream transcriptional and biological outcomes. Significance: The development of pharmacological strategies to dissociate disease-related from physiological functions of Wnt/β-catenin signaling is critical for clinical applications.

Original languageEnglish (US)
Pages (from-to)37042-37056
Number of pages15
JournalJournal of Biological Chemistry
Volume287
Issue number44
DOIs
StatePublished - Oct 26 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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