Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity

J. Reddy*, C. Harris, D. Svoboda

*Corresponding author for this work

Research output: Contribution to journalLetter

15 Citations (Scopus)

Abstract

LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar "capping"4,5 (Fig. 1). The functional significance of nucleolar "caps" is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.

Original languageEnglish (US)
Pages (from-to)659-661
Number of pages3
JournalNature
Volume217
Issue number5129
DOIs
StatePublished - Dec 1 1968

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Heliotropium
Tryptophan Oxygenase
DNA-Directed RNA Polymerases
RNA
Pyrrolizidine Alkaloids
RNA Replicase
Liver Neoplasms
DNA
lasiocarpine

ASJC Scopus subject areas

  • General

Cite this

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title = "Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity",
abstract = "LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar {"}capping{"}4,5 (Fig. 1). The functional significance of nucleolar {"}caps{"} is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.",
author = "J. Reddy and C. Harris and D. Svoboda",
year = "1968",
month = "12",
day = "1",
doi = "10.1038/217659a0",
language = "English (US)",
volume = "217",
pages = "659--661",
journal = "Nature",
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Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity. / Reddy, J.; Harris, C.; Svoboda, D.

In: Nature, Vol. 217, No. 5129, 01.12.1968, p. 659-661.

Research output: Contribution to journalLetter

TY - JOUR

T1 - Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity

AU - Reddy, J.

AU - Harris, C.

AU - Svoboda, D.

PY - 1968/12/1

Y1 - 1968/12/1

N2 - LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar "capping"4,5 (Fig. 1). The functional significance of nucleolar "caps" is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.

AB - LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar "capping"4,5 (Fig. 1). The functional significance of nucleolar "caps" is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.

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