Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity

J. Reddy; C. Harris; D. Svoboda

doi:10.1038/217659a0

Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity

J. Reddy^*, C. Harris, D. Svoboda

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Letter › peer-review

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Abstract

LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar "capping"4,5 (Fig. 1). The functional significance of nucleolar "caps" is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.

Original language	English (US)
Pages (from-to)	659-661
Number of pages	3
Journal	Nature
Volume	217
Issue number	5129
DOIs	https://doi.org/10.1038/217659a0
State	Published - 1968

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abstract = "LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar {"}capping{"}4,5 (Fig. 1). The functional significance of nucleolar {"}caps{"} is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.",

author = "J. Reddy and C. Harris and D. Svoboda",

year = "1968",

doi = "10.1038/217659a0",

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T1 - Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity

AU - Reddy, J.

AU - Harris, C.

AU - Svoboda, D.

PY - 1968

Y1 - 1968

N2 - LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar "capping"4,5 (Fig. 1). The functional significance of nucleolar "caps" is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.

AB - LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar "capping"4,5 (Fig. 1). The functional significance of nucleolar "caps" is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.

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ER -

Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity

Abstract

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