Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity

J. Reddy*, C. Harris, D. Svoboda

*Corresponding author for this work

Research output: Contribution to journalLetter

15 Scopus citations

Abstract

LASIOCARPINE, a pyrrolizidine alkaloid derived from Heliotropium lasiocarpium or from Heliotropium europaeum, produces chronic liver damage and cancer in rats and other laboratory animals1-3, and it induces nucleolar "capping"4,5 (Fig. 1). The functional significance of nucleolar "caps" is poorly understood. They are probably related to alterations in DNA-directed RNA synthesis and RNA polymerase activity6-8.

Original languageEnglish (US)
Pages (from-to)659-661
Number of pages3
JournalNature
Volume217
Issue number5129
DOIs
StatePublished - Dec 1 1968

ASJC Scopus subject areas

  • General

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