Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the α2 domain of HLA-A2

Peter Parham*, Carol Clayberger, Sherri L. Zorn, David S. Ludwig, Gary K. Schoolnik, Alan M. Krensky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

Class I major histocompatibility complex (MHC) molecules function in the recognition of antigens by cytotoxic T lymphocytes (CTL)1,2. Although this biological role is firmly established and much has been learnt about their structure and polymorphic variation3-6, little is known of the regions of class I molecules that are involved in functional interactions with components of the T-cell surface. Here we show that peptides derived from residues 98-113 of the α2 domain of HLA-A2 specifically inhibit the recognition of target cells by many HLA-A2-specific CTL. In addition to identifying a region that is probably involved in binding the T-cell receptor these results raise the possibility that alloreactive CTL may recognize degraded fragments of class I histocompatibility antigens.

Original languageEnglish (US)
Pages (from-to)625-628
Number of pages4
JournalNature
Volume325
Issue number6105
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the α<sub>2</sub> domain of HLA-A2'. Together they form a unique fingerprint.

Cite this