Inhibition of angiogenesis by thrombospondin-2

O. V. Volpert, S. S. Tolsma, S. Pellerin, J. J. Feige, H. Chen, D. F. Mosher, N. Bouck

Research output: Contribution to journalArticlepeer-review

187 Scopus citations

Abstract

To assess the ability of proteins of the thrombospondin family to inhibit angiogenesis, recombinant murine thrombospondin-2, bovine thrombospondin-2/CISP and thrombospondin-5/COMP were purified and tested for ability to block the migration of capillary endothelial cells towards a variety of inducers and to inhibit neovascularization induced in the rat cornea. Both preparations of thrombospondin-2 were active inhibitors in vitro and in vivo whereas thrombospondin-5/COMP was inactive. These results define thrombospondin-2 as a newly identified naturally occurring inhibitor of angiogenesis and suggest that the properdin-like type 1 modules that it shares with antiangiogenic thrombospondin-l and are missing in thrombospondin-5/COMP could contribute to this activity.

Original languageEnglish (US)
Pages (from-to)326-332
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume217
Issue number1
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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