Inhibition of basophil histamine release by anti-inflammatory steroids

Robert P. Schleimer*, Lawrence M. Liechtenstein, Elizabeth Gillespie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

The release of histamine from human leukocytes is a useful in vitro model for studying allergic disease1. Many of the drugs used in the treatment of allergy and asthma (for example, isoprenaline and theophylline) are effective inhibitors of in vitro histamine release2. However, the anti-inflammatory steroids have not been found to inhibit the in vitro release of histamine from mast cells or basophils activated by immunological stimuli3-6. In view of the fact that the in vivo anti-allergic effects of steroids occur only 12-24 h after administration7, we have re-examined the effects of these drugs on IgE-mediated histamine release from human basophils after prolonged incubations. We report here a time-dependent inhibition of histamine release from human basophils by glucocortico-steroids. The relative activity of a series of steroids as inhibitors of histamine release correlates well with the relative in vivo anti-inflammatory activity of the same compounds. These results suggest that the basophil may be an in vivo target of the anti-inflammatory steroids and that inhibition of this cell type may account for some of the activity of steroids in preventing inflammation.

Original languageEnglish (US)
Pages (from-to)454-455
Number of pages2
JournalNature
Volume292
Issue number5822
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • General

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