TY - JOUR
T1 - Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells
AU - Lee Chang, Catalina
AU - Bodogai, Monica
AU - Martin-Montalvo, Alejandro
AU - Wejksza, Katarzyna
AU - Sanghvi, Mitesh
AU - Moaddel, Ruin
AU - De Cabo, Rafael
AU - Biragyn, Arya
PY - 2013/10/15
Y1 - 2013/10/15
N2 - We reported previously that tumor-evoked regulatory B cells (tBregs) play an essential role in breast cancer lung metastasis by inducing TGF-β-dependent conversion of metastasis-promoting Foxp3+ regulatory T cells (Tregs). In this article, we show that resveratrol (RSV), a plant-derived polyphenol, at low and noncytotoxic doses for immune cells, can efficiently inhibit lung metastasis in mice. The mechanism of this process is that RSV inactivates Stat3, preventing the generation and function of tBregs, including expression of TGF-β. As a result, it frees antitumor effector immune responses by disabling tBreg-induced conversion of Foxp3+ Tregs. We propose that low doses of RSV may also benefit humans by controlling cancer escape-promoting tBregs/Tregs without nonspecific inactivation of effector immune cells.
AB - We reported previously that tumor-evoked regulatory B cells (tBregs) play an essential role in breast cancer lung metastasis by inducing TGF-β-dependent conversion of metastasis-promoting Foxp3+ regulatory T cells (Tregs). In this article, we show that resveratrol (RSV), a plant-derived polyphenol, at low and noncytotoxic doses for immune cells, can efficiently inhibit lung metastasis in mice. The mechanism of this process is that RSV inactivates Stat3, preventing the generation and function of tBregs, including expression of TGF-β. As a result, it frees antitumor effector immune responses by disabling tBreg-induced conversion of Foxp3+ Tregs. We propose that low doses of RSV may also benefit humans by controlling cancer escape-promoting tBregs/Tregs without nonspecific inactivation of effector immune cells.
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U2 - 10.4049/jimmunol.1300606
DO - 10.4049/jimmunol.1300606
M3 - Article
C2 - 24043896
AN - SCOPUS:84885451683
SN - 0022-1767
VL - 191
SP - 4141
EP - 4151
JO - Journal of Immunology
JF - Journal of Immunology
IS - 8
ER -