TY - GEN
T1 - Inhibition of extratumoral chondroitin sulfate glycosaminoglycans stems glioma cell invasion
AU - Logun, Meghan
AU - Simchick, Greg
AU - Zhao, Wujun
AU - Mao, Leidong
AU - Zhao, Qun
AU - Mukherjee, Subhas
AU - Brat, Daniel
AU - Karumbaiah, Lohitash
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Over the past 50 years, patient prognosis for glioblastoma (GBM) has not improved from an average survival of 12 months with best standard of care treatment. Currently available treatments are unable to mitigate the rapid proliferation and cellular invasion that are characteristic of GBM. The invasive spread of GBM has been linked to tumor microenvironment (TME)-specific changes in sulfated chondroitin sulfate glycosaminoglycan (CS-GAG) composition. The role of CS-GAGs in tumor invasion and the effects of blocking CS-GAG activity on tumor progression have not yet been investigated. We hypothesize that GBM invasion is exacerbated by the selective upregulation of oversulfated CS-GAGs in the TME, and that inhibiting CS-GAG signaling in the TME will stem GBM invasion.
AB - Statement of Purpose: Over the past 50 years, patient prognosis for glioblastoma (GBM) has not improved from an average survival of 12 months with best standard of care treatment. Currently available treatments are unable to mitigate the rapid proliferation and cellular invasion that are characteristic of GBM. The invasive spread of GBM has been linked to tumor microenvironment (TME)-specific changes in sulfated chondroitin sulfate glycosaminoglycan (CS-GAG) composition. The role of CS-GAGs in tumor invasion and the effects of blocking CS-GAG activity on tumor progression have not yet been investigated. We hypothesize that GBM invasion is exacerbated by the selective upregulation of oversulfated CS-GAGs in the TME, and that inhibiting CS-GAG signaling in the TME will stem GBM invasion.
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M3 - Conference contribution
AN - SCOPUS:85065406481
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 647
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -