Inhibition of extratumoral chondroitin sulfate glycosaminoglycans stems glioma cell invasion

Meghan Logun, Greg Simchick, Wujun Zhao, Leidong Mao, Qun Zhao, Subhas Mukherjee, Daniel Brat, Lohitash Karumbaiah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Over the past 50 years, patient prognosis for glioblastoma (GBM) has not improved from an average survival of 12 months with best standard of care treatment. Currently available treatments are unable to mitigate the rapid proliferation and cellular invasion that are characteristic of GBM. The invasive spread of GBM has been linked to tumor microenvironment (TME)-specific changes in sulfated chondroitin sulfate glycosaminoglycan (CS-GAG) composition. The role of CS-GAGs in tumor invasion and the effects of blocking CS-GAG activity on tumor progression have not yet been investigated. We hypothesize that GBM invasion is exacerbated by the selective upregulation of oversulfated CS-GAGs in the TME, and that inhibiting CS-GAG signaling in the TME will stem GBM invasion.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages647
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Logun, M., Simchick, G., Zhao, W., Mao, L., Zhao, Q., Mukherjee, S., Brat, D., & Karumbaiah, L. (2019). Inhibition of extratumoral chondroitin sulfate glycosaminoglycans stems glioma cell invasion. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (pp. 647). (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.