Inhibition of follicle-stimulating hormone secretion from gonadotroph adenomas by repetitive administration of a gonadotropin-releasing hormone antagonist

Leela Daneshdoost, Spyros N. Pavlou, Mark E. Molitch, Thomas A. Gennarelli, Peter J. Savino, Robert C. Sergott, Thomas M. Bosley, Jean E. River, Wylie W. Vale, Peter J. Snyder*

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

As a preliminary step in searching for a pharmacological treatment for gonadotroph adenomas, we administered the GnRH antagonist analog Nal-Glu GnRH to five patients, four men and a woman, with FSH-secreting gonadotroph adenomas in order to determine its effect on FSH secretion. Administration of a single 10-mg dose of Nal-Glu GnRH to four of the patients produced a significant decrease in the serum FSH concentration in two patients and returned the FSH level t o normal in only one. Administration of 5 mg Nal-Glu every 12h for 7 days, however, produced a significant (P < 0.001) decrease, and to within the normal range, in four of the five patients (mean ± SEM, 32.7 ± 5.6 IU/L during the 3 days before treatment and 9.8 ± 1.4 IU/L during the last 3 days of treatment). Also, in response to the 7-day treatment, LH fell significantly in all five patients, a-subunit fell in three, and testosterone fell in all four men. Administration for 6 weeks of the GnRH agonist analog leuprolide did not decrease the serum FSH concentration of one of the patients whose serum FSH did decrease in response to Nal-Glu GnRH. We conclude that repetitive administration of Nal-Glu GnRH may often inhibit FSH secretion by gonadotroph adenomas and that FSH secretion by gonadotroph adenomas may be dependent on endogenous GnRH secretion.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume71
Issue number1
DOIs
StatePublished - Jul 1990

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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