Inhibition of glycogen synthase kinase-3

Andrei V. Ougolkov, Daniel D. Billadeau

Research output: Chapter in Book/Report/Conference proceedingChapter

18 Scopus citations


There are two homologous forms of glycogen synthase kinase (GSK)-3, GSK-3α and GSK-3β, which play overlapping roles in the regulation of Wnt, Hedgehog, and insulin pathways, as well as the activation of nuclear factor (NF)-kB-mediated gene transcription. These signaling pathways regulate gene transcription, cell cycle, apoptosis, inflammation, glucose metabolism, stem-cell renewal, and differentiation. More than 50 GSK-3 inhibitors representing a wide range of chemical structures have already been identified, and their utility in the treatment of type II diabetes mellitus, Alzheimer's disease, bipolar diseases, cancer, and other human pathologies is currently being investigated. Here, we discuss two methods of GSK-3 inhibition, which can be used to determine the involvement of GSK-3 in a cellular process of interest.

Original languageEnglish (US)
Title of host publicationWnt Signaling
Subtitle of host publicationPathway Methods and Mammalian Models
EditorsElizabeth Vincan
Number of pages9
StatePublished - 2008

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Glycogen synthase
  • Glycogen synthase kinase-3
  • β-catenin

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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