Abstract
6-ketocholestanol. a naturally occurring oxygenated sterol, when incubated with human neutrophils (PMN), can inhibit superoxide and hydrogen peroxide generation in a dose-dependent fashion. This is accompanied by inhibition of stimulated PMN aggregation without alteration in cellular viability. This inhibitory effect is not affected by washing of the cells, and cannot be blocked by the addition of free cholesterol to the medium. These data are consistent with prior observations which showed an inhibitory effect on PMN chemotaxis by certain oxygenated sterol compounds. and support the hypothesis that certain oxygenated sterols can affect a variety of human PMN functions by a mechanism that may involve perturbation of the plasma membrane.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 185-193 |
| Number of pages | 9 |
| Journal | Free Radical Research |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1990 |
Funding
I Supported by a grant from the American Academy of Allergy and Immunology. Please address reprint requests to Dr Gordon at: Section of HematologyiOncology. Northwestern University Medical School. 303 East Chicago Avenue. Chicago. Illinois 6061 I. Tel. (312) 908-5284.
Keywords
- 6-ketocholestanol
- Neutrophils
- Sterols
ASJC Scopus subject areas
- Biochemistry