Inhibition of oviducal sperm transport in rabbits immunized against sperm-specific lactate dehydrogenase (LDH-C4)

John W. Kille*, Erwin Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Known quantities of spermatozoa were placed directly into the oviducts, via the utero-tubal junction, of rabbits which had been immunized systemically with either Freund's complete adjuvant plus saline (control) or with adjuvant and saline containing sperm-specific lactate dehydrogenase (LDH-C4; immune). Sperm transport through the oviducts was estimated by determining the percentage of sperm recovered from a flask connected to the fimbriae. An average of 26.1% of inseminated sperm was recovered from control oviducts while only 6.8% of such sperm were recovered from immune oviducts (the difference is significant; P < 0.002). This reduction in sperm transport occurred in the presence of antibody to LDH-C4 in the oviducal fluid of immune rabbits, and is probably a major factor contributing to the infertility of females immunized against LDH-C4.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalJournal of Reproductive Immunology
Volume2
Issue number1
DOIs
StatePublished - Apr 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

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