Inhibition of protein kinase C activity promotes the neurotrophic action of epidermal and basic fibroblast growth factors

Richard S. Morrison; Janet L. Gross; Joseph R. Moskal

doi:10.1016/0006-8993(88)90325-3

Inhibition of protein kinase C activity promotes the neurotrophic action of epidermal and basic fibroblast growth factors

Richard S. Morrison^*, Janet L. Gross, Joseph R. Moskal

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In primary neuronal cultures the activation of protein kinase C (PKC) by tumor-promoting phorbol esters blocked growth factor-induced neuronal survival and neurite extension. Depletion of PKC markedly facilitated both epidermal growth factor and basic fibroblast growth factor-inducible neurite extension. Inhibition of PKC by H-7 also stimulated neurite extension. These results suggest that down-regulation of PKC in neurons may be required for trophic factor action.

Original language	English (US)
Pages (from-to)	141-146
Number of pages	6
Journal	Brain research
Volume	473
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)90325-3
State	Published - Nov 8 1988

Keywords

Basic fibroblash growth factor
Epidermal growth factor
Neurite outgrowth
Neuron
Protein kinase C
Trophic factor

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

Access to Document

10.1016/0006-8993(88)90325-3

Cite this

@article{19111b867fbe4431a552a3c611abc667,

title = "Inhibition of protein kinase C activity promotes the neurotrophic action of epidermal and basic fibroblast growth factors",

abstract = "In primary neuronal cultures the activation of protein kinase C (PKC) by tumor-promoting phorbol esters blocked growth factor-induced neuronal survival and neurite extension. Depletion of PKC markedly facilitated both epidermal growth factor and basic fibroblast growth factor-inducible neurite extension. Inhibition of PKC by H-7 also stimulated neurite extension. These results suggest that down-regulation of PKC in neurons may be required for trophic factor action.",

keywords = "Basic fibroblash growth factor, Epidermal growth factor, Neurite outgrowth, Neuron, Protein kinase C, Trophic factor",

author = "Morrison, {Richard S.} and Gross, {Janet L.} and Moskal, {Joseph R.}",

year = "1988",

month = nov,

day = "8",

doi = "10.1016/0006-8993(88)90325-3",

language = "English (US)",

volume = "473",

pages = "141--146",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Inhibition of protein kinase C activity promotes the neurotrophic action of epidermal and basic fibroblast growth factors

AU - Morrison, Richard S.

AU - Gross, Janet L.

AU - Moskal, Joseph R.

PY - 1988/11/8

Y1 - 1988/11/8

N2 - In primary neuronal cultures the activation of protein kinase C (PKC) by tumor-promoting phorbol esters blocked growth factor-induced neuronal survival and neurite extension. Depletion of PKC markedly facilitated both epidermal growth factor and basic fibroblast growth factor-inducible neurite extension. Inhibition of PKC by H-7 also stimulated neurite extension. These results suggest that down-regulation of PKC in neurons may be required for trophic factor action.

AB - In primary neuronal cultures the activation of protein kinase C (PKC) by tumor-promoting phorbol esters blocked growth factor-induced neuronal survival and neurite extension. Depletion of PKC markedly facilitated both epidermal growth factor and basic fibroblast growth factor-inducible neurite extension. Inhibition of PKC by H-7 also stimulated neurite extension. These results suggest that down-regulation of PKC in neurons may be required for trophic factor action.

KW - Basic fibroblash growth factor

KW - Epidermal growth factor

KW - Neurite outgrowth

KW - Neuron

KW - Protein kinase C

KW - Trophic factor

UR - http://www.scopus.com/inward/record.url?scp=0024227042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024227042&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(88)90325-3

DO - 10.1016/0006-8993(88)90325-3

M3 - Article

C2 - 3264744

AN - SCOPUS:0024227042

SN - 0006-8993

VL - 473

SP - 141

EP - 146

JO - Brain research

JF - Brain research

IS - 1

ER -

Inhibition of protein kinase C activity promotes the neurotrophic action of epidermal and basic fibroblast growth factors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this