Inhibition of protein kinase C activity promotes the neurotrophic action of epidermal and basic fibroblast growth factors

Richard S. Morrison*, Janet L. Gross, Joseph R. Moskal

*Corresponding author for this work

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

In primary neuronal cultures the activation of protein kinase C (PKC) by tumor-promoting phorbol esters blocked growth factor-induced neuronal survival and neurite extension. Depletion of PKC markedly facilitated both epidermal growth factor and basic fibroblast growth factor-inducible neurite extension. Inhibition of PKC by H-7 also stimulated neurite extension. These results suggest that down-regulation of PKC in neurons may be required for trophic factor action.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalBrain research
Volume473
Issue number1
DOIs
StatePublished - Nov 8 1988

Keywords

  • Basic fibroblash growth factor
  • Epidermal growth factor
  • Neurite outgrowth
  • Neuron
  • Protein kinase C
  • Trophic factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Inhibition of protein kinase C activity promotes the neurotrophic action of epidermal and basic fibroblast growth factors'. Together they form a unique fingerprint.

  • Cite this