Inhibition of rat glioma growth by neomycin. Preliminary report

P. Cuevas*, F. Carceller, D. Diaz-González, B. Cuevas, A. Fernández, I. Garcia-Gómez, M. Dujovny

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Tumor development is known to largely depend on angiogenesis, and nuclear translocation of angiogenic factors is one of the crucial steps in tumor angiogenesis. This preliminary study was designed to investigate the suppression of tumor growth by neomycin, an inhibitor of nuclear translocation of several angiogenic factors overexpressed in gliomas. We found that intratumoral osmotic pump delivery of 10 mM neomycin caused significant inhibition of C6 glioma tumor development (85%) in rats. The data establish neomycin as a potential inhibitor of angiogenesis-dependent tumor growth and raise the possibility for its use as therapy in pathologies in which neovascularization is involved, including neoplasia.

Original languageEnglish (US)
Pages (from-to)522-524
Number of pages3
JournalNeurological research
Volume24
Issue number6
DOIs
StatePublished - Sep 1 2002
Externally publishedYes

Keywords

  • Angiogenic factors
  • Glioma
  • Neomycin
  • Tumor growth inhibition

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Inhibition of rat glioma growth by neomycin. Preliminary report'. Together they form a unique fingerprint.

  • Cite this

    Cuevas, P., Carceller, F., Diaz-González, D., Cuevas, B., Fernández, A., Garcia-Gómez, I., & Dujovny, M. (2002). Inhibition of rat glioma growth by neomycin. Preliminary report. Neurological research, 24(6), 522-524. https://doi.org/10.1179/016164102101200375