Inhibition of respiratory syncytial, parainfluenza 3 and measles viruses by 2-deoxy-d-glucose

David S. Hodes; Thomas J. Schnitzer; Anthony R. Kalica; Ena Camargo; Robert M. Chanock

doi:10.1016/0042-6822(75)90385-2

Inhibition of respiratory syncytial, parainfluenza 3 and measles viruses by 2-deoxy-d-glucose

David S. Hodes^*, Thomas J. Schnitzer, Anthony R. Kalica, Ena Camargo, Robert M. Chanock

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

2-Deoxy-d-glucose was found to inhibit the replication and cytopathic effects of respiratory syncytial, parainfluenza 3 and measles viruses. The effects of the drug were completely reversible and appeared directed against viral functions occurring in the second half of the viral growth cycle. At least some viral functions appeared to be unaffected by the agent. Electron microscopic studies with a temperature-sensitive mutant of respiratory syncytial virus indicated that 2-deoxy-d-glucose produced a morphological change. Surface projections were greatly reduced in virions grown in the presence of the drug.

Original language	English (US)
Pages (from-to)	201-208
Number of pages	8
Journal	Virology
Volume	63
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(75)90385-2
State	Published - Jan 1975

ASJC Scopus subject areas

Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0042-6822(75)90385-2

Cite this

@article{eba682e257f942c988309328ec575033,

title = "Inhibition of respiratory syncytial, parainfluenza 3 and measles viruses by 2-deoxy-d-glucose",

abstract = "2-Deoxy-d-glucose was found to inhibit the replication and cytopathic effects of respiratory syncytial, parainfluenza 3 and measles viruses. The effects of the drug were completely reversible and appeared directed against viral functions occurring in the second half of the viral growth cycle. At least some viral functions appeared to be unaffected by the agent. Electron microscopic studies with a temperature-sensitive mutant of respiratory syncytial virus indicated that 2-deoxy-d-glucose produced a morphological change. Surface projections were greatly reduced in virions grown in the presence of the drug.",

author = "Hodes, \{David S.\} and Schnitzer, \{Thomas J.\} and Kalica, \{Anthony R.\} and Ena Camargo and Chanock, \{Robert M.\}",

year = "1975",

month = jan,

doi = "10.1016/0042-6822(75)90385-2",

language = "English (US)",

volume = "63",

pages = "201--208",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Inhibition of respiratory syncytial, parainfluenza 3 and measles viruses by 2-deoxy-d-glucose

AU - Hodes, David S.

AU - Schnitzer, Thomas J.

AU - Kalica, Anthony R.

AU - Camargo, Ena

AU - Chanock, Robert M.

PY - 1975/1

Y1 - 1975/1

N2 - 2-Deoxy-d-glucose was found to inhibit the replication and cytopathic effects of respiratory syncytial, parainfluenza 3 and measles viruses. The effects of the drug were completely reversible and appeared directed against viral functions occurring in the second half of the viral growth cycle. At least some viral functions appeared to be unaffected by the agent. Electron microscopic studies with a temperature-sensitive mutant of respiratory syncytial virus indicated that 2-deoxy-d-glucose produced a morphological change. Surface projections were greatly reduced in virions grown in the presence of the drug.

AB - 2-Deoxy-d-glucose was found to inhibit the replication and cytopathic effects of respiratory syncytial, parainfluenza 3 and measles viruses. The effects of the drug were completely reversible and appeared directed against viral functions occurring in the second half of the viral growth cycle. At least some viral functions appeared to be unaffected by the agent. Electron microscopic studies with a temperature-sensitive mutant of respiratory syncytial virus indicated that 2-deoxy-d-glucose produced a morphological change. Surface projections were greatly reduced in virions grown in the presence of the drug.

UR - http://www.scopus.com/inward/record.url?scp=0016437924&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016437924&partnerID=8YFLogxK

U2 - 10.1016/0042-6822(75)90385-2

DO - 10.1016/0042-6822(75)90385-2

M3 - Article

C2 - 163047

AN - SCOPUS:0016437924

SN - 0042-6822

VL - 63

SP - 201

EP - 208

JO - Virology

JF - Virology

IS - 1

ER -

Inhibition of respiratory syncytial, parainfluenza 3 and measles viruses by 2-deoxy-d-glucose

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this