Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone

Sambasiva Rao Musunuri*, V. Subbarao, Anjana V Yeldandi, Janardan K Reddy

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats. We have examined the effect of dehydroepi-androsterone (DHEA), a steroid hormone with antimitotic and anticarcinogenic properties, on spontaneous Leydig cell tumorigenesis. Fifteen-week-old male F-344 rats were fed a diet containing DHEA (0.45% w/w) for 84 weeks. At the termination of experiment none of the 13 rats had Leydig cell hyperplasia or Leydig cell tumors. All the eight control rats of comparable age had Leydig cell tumors. These findings suggest that DHEA is a potent inhibitor of spontaneous Leydig cell tumors of testis in aged rats.

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalCancer Letters
Volume65
Issue number2
DOIs
StatePublished - Aug 14 1992

Keywords

  • anticarcinogen
  • steroids
  • testis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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