Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone

M. S. Rao; V. Subbarao; A. V. Yeldandi; J. K. Reddy

doi:10.1016/0304-3835(92)90155-O

Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone

M. S. Rao^*, V. Subbarao, A. V. Yeldandi, J. K. Reddy

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats. We have examined the effect of dehydroepi-androsterone (DHEA), a steroid hormone with antimitotic and anticarcinogenic properties, on spontaneous Leydig cell tumorigenesis. Fifteen-week-old male F-344 rats were fed a diet containing DHEA (0.45% w/w) for 84 weeks. At the termination of experiment none of the 13 rats had Leydig cell hyperplasia or Leydig cell tumors. All the eight control rats of comparable age had Leydig cell tumors. These findings suggest that DHEA is a potent inhibitor of spontaneous Leydig cell tumors of testis in aged rats.

Original language	English (US)
Pages (from-to)	123-126
Number of pages	4
Journal	Cancer Letters
Volume	65
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(92)90155-O
State	Published - Aug 14 1992

Funding

This researchw as supportedb y Veterans AffairsM erit Review Programa nd NIH Grant GM23750.

Keywords

anticarcinogen
steroids
testis

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(92)90155-O

Cite this

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title = "Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone",

abstract = "The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats. We have examined the effect of dehydroepi-androsterone (DHEA), a steroid hormone with antimitotic and anticarcinogenic properties, on spontaneous Leydig cell tumorigenesis. Fifteen-week-old male F-344 rats were fed a diet containing DHEA (0.45% w/w) for 84 weeks. At the termination of experiment none of the 13 rats had Leydig cell hyperplasia or Leydig cell tumors. All the eight control rats of comparable age had Leydig cell tumors. These findings suggest that DHEA is a potent inhibitor of spontaneous Leydig cell tumors of testis in aged rats.",

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author = "Rao, {M. S.} and V. Subbarao and Yeldandi, {A. V.} and Reddy, {J. K.}",

note = "Funding Information: This researchw as supportedb y Veterans AffairsM erit Review Programa nd NIH Grant GM23750.",

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doi = "10.1016/0304-3835(92)90155-O",

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T1 - Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone

AU - Rao, M. S.

AU - Subbarao, V.

AU - Yeldandi, A. V.

AU - Reddy, J. K.

N1 - Funding Information: This researchw as supportedb y Veterans AffairsM erit Review Programa nd NIH Grant GM23750.

PY - 1992/8/14

Y1 - 1992/8/14

N2 - The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats. We have examined the effect of dehydroepi-androsterone (DHEA), a steroid hormone with antimitotic and anticarcinogenic properties, on spontaneous Leydig cell tumorigenesis. Fifteen-week-old male F-344 rats were fed a diet containing DHEA (0.45% w/w) for 84 weeks. At the termination of experiment none of the 13 rats had Leydig cell hyperplasia or Leydig cell tumors. All the eight control rats of comparable age had Leydig cell tumors. These findings suggest that DHEA is a potent inhibitor of spontaneous Leydig cell tumors of testis in aged rats.

AB - The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats. We have examined the effect of dehydroepi-androsterone (DHEA), a steroid hormone with antimitotic and anticarcinogenic properties, on spontaneous Leydig cell tumorigenesis. Fifteen-week-old male F-344 rats were fed a diet containing DHEA (0.45% w/w) for 84 weeks. At the termination of experiment none of the 13 rats had Leydig cell hyperplasia or Leydig cell tumors. All the eight control rats of comparable age had Leydig cell tumors. These findings suggest that DHEA is a potent inhibitor of spontaneous Leydig cell tumors of testis in aged rats.

KW - anticarcinogen

KW - steroids

KW - testis

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Inhibition of spontaneous testicular Leydig cell tumor development in F-344 rats by dehydroepiandrosterone

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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