Inhibition of the Mixed Lymphocyte Culture Response by Antibody Following Successful Human Renal Transplantation

BRACK G. HATTLER*, CHARLES KARESH, JOSHUA MILLER

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Immunoglobulin G, appearing after several months in the serum of a recipient of a successful kidney transplant from a closely matched sibling donor, was demonstrated to progressively inhibit unidirectional mixed lymphocyte cultures when donor lymphocytes were used either in responding or stimulating cell populations. The active recipient IgG had no effect in cultures in which donor cells were not used, nor did IgG obtained from other individuals show nonspecific inhibitory effects on cultures containing donor cells. It is suggested that the MLC inhibitory immunoglobulin may serve an immunoregulatory function after renal transplantation.

Original languageEnglish (US)
Pages (from-to)270-275
Number of pages6
JournalTissue Antigens
Volume1
Issue number6
DOIs
StatePublished - Nov 1971

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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