Inhibition of transmitter release by adenosine: are Ca2+ currents depressed or are the intracellular effects of Ca2+ impaired?

Eugene M Silinsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

It has been suggested that blockade of nerve terminal Ca2+ channels by extracellular adenosine is responsible for the inhibitory effects of adenosine and its congeners on the secretion of neurotransmitter substances. Several lines of evidence, however, are not in accord with this suggestion. Eugene M. Silinsky presents evidence to indicate that the impairment of Ca2+-dependent processes at an intracellular site associated with the secretory apparatus provides the best single explanation for the inhibitory effects of adenosine derivatives on transmitter release.

Original languageEnglish (US)
Pages (from-to)180-185
Number of pages6
JournalTrends in Pharmacological Sciences
Volume7
Issue numberC
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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